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Temporal Specification of Basal Forebrain Circuitry

Award Number: R37MH119156
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Temporal Specification of Basal Forebrain Circuitry - Project Summary The septal complex which regulates a wide range of social, and emotional behaviors can be classified into medial (MS) and lateral (LS) regions. The medial septum is composed of cholinergic and GABAergic neurons that primarily project to the hippocampus. The lateral septum is composed of a diverse array of GABAergic projection neurons that receives reciprocal input from numerous brain regions known to regulate emotional and motivational states. The lateral septal nuclei are strongly implicated in stress and anxiety where previous studies indicate a role for the septum in both promoting and suppressing anxiety related behavior, including circuits involved in mediating enduring behavioral changes resulting from early life stress and social trauma. Dysfunction of septal neurons is thought to play a significant role in the pathophysiology of a variety of psychiatric disorders including schizophrenia, bipolar disorder, depression and anxiety-related disorders. Despite our growing appreciation for the importance of septal nuclei circuit function in modulating social, emotional and affective behaviors we know very little about the specific functions of the diverse septal neuron types and even less about the developmental mechanisms that create this diversity. The overall goal of this research proposal is to identify the key genetic and molecular pathways that underlie the developmental logic for the functional specialization of diverse neuronal cell types in the septum. Our studies will provide a framework for assessing the development and behavioral function of other septal neuron types and uncover targets for novel treatments for neuropsychiatric disorders that may arise from septal circuit dysfunction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $801,633 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	7	1/26/2026	NON-COMPETING CONTINUATION	$801,633
														Subtotal = $801,633

Issue Date FY: 2025 ( Subtotal = $491,107 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	6	9/19/2025	NON-COMPETING CONTINUATION	$119,909
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	6	3/18/2025	NON-COMPETING CONTINUATION	$371,198
														Subtotal = $491,107

Issue Date FY: 2024 ( Subtotal = $1,107,534 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	5	4/12/2024	COMPETING CONTINUATION	$719,324
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	002	5	8/12/2024	COMPETING CONTINUATION	$308,285
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	5	5/1/2024	COMPETING CONTINUATION	$79,925
														Subtotal = $1,107,534

Grand Total All Awards = $2,400,274

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Temporal Specification of Basal Forebrain Circuitry

Award Number: R37MH119156

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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