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Gaining insight into psychiatric disease by engineering piece by piece the human brain in vitro

Award Number: R37MH107800
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2015
PERIOD OF PERFORMANCE END DATE: 08/19/2029

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Gaining insight into psychiatric disease by engineering piece by piece the human brain in vitro - ABSTRACT The inaccessibility of human brain tissue at the molecular and cellular level has hindered therapeutic development for psychiatric disorders. Our laboratory has developed neural organoids mimicking specific brain regions from stem cells and pioneered neural assembloids to study interneuron migration and circuit formation. However, in vitro models lack the in vivo interactions and inputs necessary for complex neuropsychiatric disease modeling. We now propose generating assembloids within the in vivo rodent cortex to enhance neuronal maturation and behavioral readouts. Specifically, we will expand transplantation models by integrating glutamatergic and GABAergic neurons to model excitation-inhibition imbalances and early cortical circuit formation. We will establish transplanted forebrain assembloids, characterize their integration and functionality, and apply this model to study severe neurodevelopmental disorders caused by genetic mutations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,812,108 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	11	8/14/2025	COMPETING CONTINUATION	$3,812,108
														Subtotal = $3,812,108

Grand Total All Awards = $3,812,108

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Gaining insight into psychiatric disease by engineering piece by piece the human brain in vitro

Award Number: R37MH107800

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2015

PERIOD OF PERFORMANCE END DATE: 08/19/2029

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