Thursday, November 21, 2024 11/21/2024

Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children

Award Number: R37HD090153
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Treatment studies to date have shown pre-to-post changes in reading circuits with evidence-based remediation of reading disability (RD), establishing a neural signature of successful treatment outcome. However, insight into the neurobiological mechanisms by which treatment produces these changes requires monitoring modulations of key brain regions throughout the course of treatment. Moreover, in any cohort some RD children with highly similar profiles on standardized testing at the beginning of intervention will show large gains and others will not. In the previous grant-cycle we employed multimodal neuroimaging before, during, and after an in-school reading intervention and identified novel neurocognitive pre-treatment factors and dynamic brain/behavior changes that predict individual differences in treatment responsiveness. In the new cycle, we maintain the overarching goal of understanding variation in response to reading remediation in RD learners with dynamic brain/behavior tracking designed to yield novel insights into how remediation modifies brain organization for reading, and why it fails to do so adequately for some RD children, but in the proposed continuation, we leverage the discoveries from the initial phase (the how and why) to next examine what might constitute a more effective neurocognitive focus for treatment in minimal-responders to conventional content. With pre-learning fMRI/MRS and frequent fNIRS/EEG tracking and with both short-term adaptive learning experiments and longer-term Educational Technology based learning programs we vary emphasis on orthographic, phonological, and component process training as we seek to match learning content to individual differences in neurocognitive organization for these component processes. Project Summary/Abstract Page 6 The proposed research examines the neurocognitive bases of treatment response to evidence-based learning programs for reading remediation. We use pre and post treatment neuroimaging and frequent neuroimaging during the course of treatment 1) to gain new insights into how treatment modulates brain organization for literacy, language learning, and remediation; 2) why it fails todo so for some children, and 3) what might constitute a more beneficial focus in minimal-responders. The proposed research represents a key step towards the development of comprehensive and mechanistic models of the neural underpinnings of typical and atypical reading development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $653,894 )
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Child Health and Human Development Extramural Research	004	8	9/10/2024	SUPPLEMENT FOR EXPANSION	$64,384
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Child Health and Human Development Extramural Research	003	8	8/21/2024	NON-COMPETING CONTINUATION	$589,510
2024	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Child Health and Human Development Extramural Research	002	7	3/15/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$807,083
2024	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	6	3/15/2024	EXTENSION WITH OR WITHOUT FUNDS	-$807,083
2024	2021	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	5	11/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $653,894

Issue Date FY: 2023 ( Subtotal = $595,463 )
2023	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Child Health and Human Development Extramural Research	001	7	8/24/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$595,463
2023	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	6	8/24/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $595,463

Issue Date FY: 2022 ( Subtotal = $854,300 )
2022	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	6	9/6/2022	EXTENSION WITH OR WITHOUT FUNDS	$854,300
														Subtotal = $854,300

Issue Date FY: 2021 ( Subtotal = $517,606 )
2021	2021	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	5	8/10/2021	NON-COMPETING CONTINUATION	$517,606
														Subtotal = $517,606

Issue Date FY: 2020 ( Subtotal = $536,033 )
2020	2020	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	4	7/1/2020	NON-COMPETING CONTINUATION	$536,033
														Subtotal = $536,033

Issue Date FY: 2019 ( Subtotal = $534,255 )
2019	2019	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	3	7/20/2019	NON-COMPETING CONTINUATION	$534,255
														Subtotal = $534,255

Issue Date FY: 2018 ( Subtotal = $548,611 )
2018	2018	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	2	7/6/2018	NON-COMPETING CONTINUATION	$548,611
														Subtotal = $548,611

Issue Date FY: 2017 ( Subtotal = $571,184 )
2017	2017	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	1	9/11/2017	NEW	$571,184
														Subtotal = $571,184

Grand Total All Awards = $4,811,346

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Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children

Award Number: R37HD090153

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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