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Evaluation of an optimized intervention to prevent early substance use among American Indian youth: Examination of expanded impacts on youth and parents

Award Number: R37DA047926
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Evaluation of an optimized intervention to prevent early substance use among American Indian youth: Examination of expanded impacts on youth and parents - It is imperative that we continue to innovate ways to address inequities that challenge the health and well- being of American Indian (AI) youth, families, and communities. The COVID-19 pandemic disproportionately impacted Indigenous communities in the U.S. and made inequities broadly visible, but these inequities are not new. The history of oppression of Indigenous people and attempts at cultural eradication through federal policies and broken treaties has disrupted cultures and communities, and research suggests that this disruption is at the root of elevated substance use problems in these communities. AI youth initiate substance use earlier than most other youth in the U.S. and the links between early initiation and both concurrent developmental disruption and progression to problematic patterns of use are strong. The need for early prevention among AI youth is clear, and evidence suggests that leveraging the cultural strengths may be a particularly effective path toward prevention. We have been working with partners on a Northern Plains Reservation since 2009 to understand risk factors for early initiation of substance use and to develop a culturally grounded prevention program for young adolescents. We have developed and are testing the Thiwáhe Gluwáš’akapi (TG) program for young AI adolescents that reinforces family, cultural and community connections. Through a multiphase optimization trial (TG1 study), we gathered preliminary evidence of the effectiveness of TG; in a randomized controlled trial (TG2 study), we tested the effectiveness of the optimized TG program. This project (TG3 Study) moves this work forward through a hybrid implementation-effectiveness study. First, it will maximize what can be learned from data collected in the TG2 study by lengthening the follow-up period for participating youth and families to four years post-intervention and utilizing Bayesian small sample quantitative analytic methods. Second, this study will build on what was learned in the TG2 study about program delivery to foster the transition from research-based to community-based implementation, engaging existing community organizations to deliver TG to families across the reservation and gathering systematic data on implementation processes and outcomes. This study will expand our understanding of TG program effects, result in a better understanding of the optimal fit for the sustained delivery of the TG program on the Pine Ridge Reservation and begin developing infrastructure for long term program implementation. RELEVANCE (See instructions): Disparities in substance use and high rates of suicide pose significant risk to American Indian (AI) youth and persist despite efforts to create culturally tailored prevention approaches. This study will add to the evidence base regarding the effectiveness of a substance use prevention program tailored for AI youth and families and simultaneously examine community-based implementation of the program to identify strategies to support sustained delivery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $710,278 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	7	1/27/2026	NON-COMPETING CONTINUATION	$639,250
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	7	2/6/2026	NON-COMPETING CONTINUATION	$71,028
														Subtotal = $710,278

Issue Date FY: 2025 ( Subtotal = $735,338 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	6	12/17/2024	EXTENSION WITH OR WITHOUT FUNDS	$735,338
2025	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	5	6/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $735,338

Issue Date FY: 2024 ( Subtotal = $610,347 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	5	2/15/2024	NON-COMPETING CONTINUATION	$549,312
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	5	4/24/2024	NON-COMPETING CONTINUATION	$61,035
														Subtotal = $610,347

Issue Date FY: 2023 ( Subtotal = $620,323 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	4	1/30/2023	NON-COMPETING CONTINUATION	$558,290
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	4	1/31/2023	NON-COMPETING CONTINUATION	$62,033
														Subtotal = $620,323

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	3	1/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $905,365 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	3	2/24/2021	SUPPLEMENT FOR EXPANSION	$285,414
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	3	2/23/2021	NON-COMPETING CONTINUATION	$619,951
														Subtotal = $905,365

Issue Date FY: 2020 ( Subtotal = $920,939 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	2	2/20/2020	NON-COMPETING CONTINUATION	$630,443
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	2	8/17/2020	SUPPLEMENT FOR EXPANSION	$290,496
														Subtotal = $920,939

Issue Date FY: 2019 ( Subtotal = $662,912 )
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	001	1	5/23/2019	NEW	$0
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	1	3/29/2019	NEW	$662,912
														Subtotal = $662,912

Grand Total All Awards = $5,165,502

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Evaluation of an optimized intervention to prevent early substance use among American Indian youth: Examination of expanded impacts on youth and parents

Award Number: R37DA047926

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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