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Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study

Award Number: R37CA256867
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study - Abstract Approximately 70,000 adolescents and young adults are diagnosed with cancer between the ages of 15-39 in the U.S. every year. Due to their age and life stage, the experience of a cancer diagnosis as a young adult (YA) can lead to a cascade of emotional and physical challenges. A key obstacle faced by YA cancer patients is impaired social health, a complex construct that includes perceived social belonging, social support, and social network composition. YA patients report social health challenges such as maintaining existing and forming new social relationships after diagnosis, which may contribute to poor quality of life post-cancer. Diminished social health is a major risk factor for poorer health in the general population and has been found to reduce health-promoting behaviors such as physical activity, in part because of the lack of healthy opportunities and support that social contacts can provide. Cancer patients clearly benefit from greater levels of physical activity and lower levels of sedentary time as these are associated with improved quality of life, longer periods of disease-free survival, and lower mortality. Thus, understanding the relationships between social health, physical activity, and quality of life is critically important for YA cancer patients, as the impaired social health experienced by these patients may reduce their activity levels and endanger long-term health outcomes. The overall hypothesis is that social health in YA is negatively impacted following a cancer diagnosis, and that detriments in social health influence subsequent physical activity behaviors and survivorship quality of life (emotional well-being and physical function). In the proposed study, we will comprehensively prospectively assess social health over 12 months and examine its influence on activity behaviors and quality of life. Assessment will begin proximal to diagnosis when changes in social health are likely to initiate for YA cancer patients, with subsequent follow-ups at 3, 6, and 12 months. This longitudinal design will enable the examination of the dynamic changes in social health during and after therapy and its predictive influence on physical activity and quality of life. The Specific Aims are: Aim 1: we will characterize the trajectories of social health in YA cancer patients and assess their influences on quality of life in survivorship; Aim 2: we will investigate the longitudinal associations between social health and activity behaviors in YA cancer patients and test the mediational and reciprocal relationships between social health, activity behaviors, and quality of life; Aim 3: we will explore demographic and clinical moderators of the relationships between social health, activity behaviors, and quality of life. Understanding the mechanistic processes by which social health impacts activity behaviors and quality of life will inform the development of effective intervention strategies to foster social health and improve healthy survivorship for this at-risk and vulnerable population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	5	12/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $559,129 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	5	4/30/2025	NON-COMPETING CONTINUATION	$503,217
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	5	5/22/2025	NON-COMPETING CONTINUATION	$55,912
														Subtotal = $559,129

Issue Date FY: 2024 ( Subtotal = $661,571 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	002	4	9/24/2024	SUPPLEMENT FOR EXPANSION	$79,528
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	4	4/17/2024	NON-COMPETING CONTINUATION	$30,634
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	4	3/1/2024	NON-COMPETING CONTINUATION	$551,409
														Subtotal = $661,571

Issue Date FY: 2023 ( Subtotal = $631,409 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	3	3/9/2023	NON-COMPETING CONTINUATION	$631,409
														Subtotal = $631,409

Issue Date FY: 2022 ( Subtotal = $665,769 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	2	5/25/2022	NON-COMPETING CONTINUATION	$66,579
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	2	2/25/2022	NON-COMPETING CONTINUATION	$599,190
														Subtotal = $665,769

Issue Date FY: 2021 ( Subtotal = $660,272 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	1	3/1/2021	NEW	$660,272
														Subtotal = $660,272

Grand Total All Awards = $3,178,150

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Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study

Award Number: R37CA256867

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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