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A mobile sensing system to monitor symptoms during chemotherapy

Award Number: R37CA242545
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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A mobile sensing system to monitor symptoms during chemotherapy - Abstract The aims of the parent R37 grant were (1) to develop and refine a mobile sensing system that applies machine learning to smartphone and wearable sensor data to passively detect symptom burden during chemotherapy and (2) to evaluate the feasibility and acceptability of using this system in an academic oncology clinic. Since the start of the R37 award on July 1, 2019, we have enrolled 154 (77% of our target n = 200) patients into a 90-day study assessing daily and weekly symptoms and continuous behavioral sensing via wearable device and smartphone during chemotherapy, conducted interim analyses demonstrating that next-day overall symptom burden can be predicted from passive sensor data, and developed infrastructure to deploy symptom prediction models in real-time. The next logical step for the original R37 research is to integrate sensor- and machine learning- based predictions into a patient-centered digital health intervention to personalize supportive cancer care. The two-year extension will enable us to design and develop a web application that shares real-time symptom predictions with patients and uses them to trigger personalized symptom management instructions. To provide useful recommendations, we also need to develop prediction models that can predict specific, clinically significant and actionable symptoms rather than overall symptom burden. In addition, we need to determine the best way to share machine learning-based predictions and recommendations in a way that fosters trust and that supports patient autonomy as well as patient-provider communication. The R37 extension will enable us to address two new aims: (1) develop additional machine learning models to predict specific clinically meaningful and actionable symptoms and (2) design and develop a web application that integrates these predictions and uses them to inform real-time symptom management. This work falls well within the scope of the parent grant and represents continued refinement of both the clinical utility of our machine learning models as well as our integration of these models into supportive cancer care within an academic oncology clinic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $358,674 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	001	7	6/13/2025	NON-COMPETING CONTINUATION	$358,674
2025	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	5	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $358,674

Issue Date FY: 2024 ( Subtotal = $340,742 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	6	7/18/2024	EXTENSION WITH OR WITHOUT FUNDS	$340,742
														Subtotal = $340,742

Issue Date FY: 2023 ( Subtotal = $446,518 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	5	6/30/2023	NON-COMPETING CONTINUATION	$350,117
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	001	5	8/10/2023	SUPPLEMENT FOR EXPANSION	$96,401
														Subtotal = $446,518

Issue Date FY: 2022 ( Subtotal = $358,675 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	4	6/15/2022	NON-COMPETING CONTINUATION	$358,675
														Subtotal = $358,675

Issue Date FY: 2021 ( Subtotal = $361,146 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	3	6/24/2021	NON-COMPETING CONTINUATION	$361,146
														Subtotal = $361,146

Issue Date FY: 2020 ( Subtotal = $361,165 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	2	7/16/2020	NON-COMPETING CONTINUATION	$361,165
														Subtotal = $361,165

Issue Date FY: 2019 ( Subtotal = $361,184 )
2019	2019	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cancer Cause and Prevention Research	000	1	6/21/2019	NEW	$361,184
														Subtotal = $361,184

Grand Total All Awards = $2,588,104

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A mobile sensing system to monitor symptoms during chemotherapy

Award Number: R37CA242545

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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