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Advancing the implementation of evidence-based strategies for HPV vaccination in safety-net primary care settings

Award Number: R37CA242541
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Advancing the implementation of evidence-based strategies for HPV vaccination in safety-net primary care settings - ABSTRACT HPV vaccination rates remain below target levels among adolescents in the United States, which is particularly concerning in safety-net populations with persistent disparities in HPV-associated cancer burden. There are numerous evidence-based strategies (EBS) designed to encourage HPV vaccination, but few programs are routinely used, much less sustained when research studies come to an end. The major research challenge we now face is not the lack of scientific knowledge about what works, but about how to integrate and sustain effective EBS for HPV vaccination within dynamic, real-world settings. Significant disruptions due to the COVID-19 pandemic further support the need to understand implementation context and processes for long- term sustainability and equity requirements of EBS for HPV vaccination in clinics serving safety-net populations (underinsured, low-income, marginalized communities). The R37 Parent Award consists of a four-year sequential mixed-methods study that identifies multilevel, community and clinic factors associated with implementation EBS for HPV vaccination within a multi-site Federally Qualified Health Care (FQHC) system. Guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework and Rapid Assessment Procedure Informed Clinical Ethnography (RAPICE) process, our multidisciplinary team will evaluate longer-term sustainability, maintenance and equity requirements for use of EBS for HPV vaccination and identify factors that impact broader system-level adoption in this R37 Merit Extension Award. We also explore factors required for scaling-out and optimization for other settings and contexts. Specific aims include: Aim 1: Assess longer-term sustainability, maintenance and equity of HPV Vaccine EBS in demonstration clinics; and Aim 2: Identify factors and core strategies needed for broader FQHC system-wide adoption (scale-up) of EBS and inform requirements for spread to other safety-net settings (scale-out). There is a dearth of data on sustainability, adaptation, and scale-up/out within implementation science as it relates to integrating EBS for HPV vaccination in safety-net settings, as most intervention and hybrid trials have limited timeframes to rigorously examine these longer-term outcomes. This R37 MERIT Extension request will leverage two additional years of funding to carry out a logical extension of the four-year funded parent award to fill a critical research gap in longer-term sustainability and equity in EBS for HPV vaccination in safety-net settings. Data obtained will also inform a larger pragmatic trial to advance the science in adaptation and fit of EBS in diverse contexts and settings in future research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $404,861 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	003	6	5/22/2025	NON-COMPETING CONTINUATION	$40,486
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	002	6	4/10/2025	NON-COMPETING CONTINUATION	$364,375
2025	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	5	2/26/2025	EXTENSION WITH OR WITHOUT FUNDS	$2
2025	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	4	2/26/2025	NON-COMPETING CONTINUATION	-$2
														Subtotal = $404,861

Issue Date FY: 2024 ( Subtotal = $396,147 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	5	8/28/2024	EXTENSION WITH OR WITHOUT FUNDS	$396,147
														Subtotal = $396,147

Issue Date FY: 2023 ( Subtotal = $366,591 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	4	5/22/2023	NON-COMPETING CONTINUATION	$366,591
														Subtotal = $366,591

Issue Date FY: 2022 ( Subtotal = $373,553 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	3	4/21/2022	NON-COMPETING CONTINUATION	$373,553
														Subtotal = $373,553

Issue Date FY: 2021 ( Subtotal = $371,731 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	2	4/13/2021	NON-COMPETING CONTINUATION	$371,731
														Subtotal = $371,731

Issue Date FY: 2020 ( Subtotal = $386,560 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	1	8/20/2020	NEW	$386,560
														Subtotal = $386,560

Grand Total All Awards = $2,299,443

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Advancing the implementation of evidence-based strategies for HPV vaccination in safety-net primary care settings

Award Number: R37CA242541

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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