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Ultrapotent Inhibitors of Wild-type and Multi-drug Resistant HIV

Award Number: R37AI076119
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Ultrapotent Inhibitors of Wild-type and Multi-drug Resistant HIV - Please see attached page for the requested one-page abstract/project summary of the Research Plan for the entire extension period. RELEVANCE (See instructions): Islatravir (ISL, currently in phase 3 clinical trials) is an extremely potent inhibitor of HIV that blocks the virus by a different mechanism than currently approved anti-HIV drugs. This project will determine the mechanisms of action, resistance, and hypersusceptibility of second-generation HIV inhibitors based on ISL. These studies will provide important insights on the design of treatment strategies of ISL or related analogs with other approved antivirals toward achieving long-acting, safe regimens for patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $612,503 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	18	1/9/2026	NON-COMPETING CONTINUATION	$612,503
														Subtotal = $612,503

Issue Date FY: 2025 ( Subtotal = $626,362 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	17	12/27/2024	EXTENSION WITH OR WITHOUT FUNDS	$626,362
2025	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	16	6/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $626,362

Issue Date FY: 2024 ( Subtotal = $470,870 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	16	1/17/2024	NON-COMPETING CONTINUATION	$423,783
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	16	5/30/2024	NON-COMPETING CONTINUATION	$47,087
														Subtotal = $470,870

Issue Date FY: 2023 ( Subtotal = $470,524 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	15	12/29/2022	NON-COMPETING CONTINUATION	$470,524
														Subtotal = $470,524

Issue Date FY: 2022 ( Subtotal = $470,199 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	14	1/13/2022	NON-COMPETING CONTINUATION	$470,199
														Subtotal = $470,199

Issue Date FY: 2021 ( Subtotal = $469,885 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	13	1/26/2021	NON-COMPETING CONTINUATION	$469,885
														Subtotal = $469,885

Issue Date FY: 2020 ( Subtotal = $498,808 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	12	6/10/2020	COMPETING CONTINUATION	$0
2020	2020	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	12	2/12/2020	COMPETING CONTINUATION	$376,089
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	12	8/24/2020	COMPETING CONTINUATION	$122,719
														Subtotal = $498,808

Grand Total All Awards = $3,619,151

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Ultrapotent Inhibitors of Wild-type and Multi-drug Resistant HIV

Award Number: R37AI076119

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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