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Host responses to Mycobacterium infection in Zebrafish.

Award Number: R37AI054503
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2017
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Host responses to Mycobacterium infection in Zebrafish. - We have used the zebrafish model to detail the host-pathogen interface in tuberculosis, and our discoveries have led to a more nuanced understanding of the role of inflammation, macrophages and granulomas in infection. In so doing, we have also achieved a better understanding of fundamental host processes particularly those involving macrophages and inflammation. In this next phase of the grant, we will continue to characterize the role of newly-identified host factors that alter mycobacterial infection. Some of these were already identified but not fully characterized in the last funding period, and others will be identified in the zebrafish mutant screen that we are continuing now, using the comprehensive sequenced zebrafish mutant library that has been created by the Sanger Institute and made available to us. Comprehensive transcriptomics will also be carried out for us at the Sanger Institute with full bioinformatics support, leaving us to focus on the phenotypic characterization of the mutants with altered susceptibility. With advances in microscopic imaging capability that are continuously occurring in our laboratory, and the use of pharmacological approaches for additional pathway dissection and drug identification, we hope to have an accelerated pace of discovery during this next phase. RELEVANCE (See instnJctions): Tuberculosis is a leading cause of death worldwide and a growing global health concern. TB has been difficult to eradicate due to a combination of factors, including the development of antibiotic resistance. Our research proposes to identify strategies and molecules that can direct development of new classes of host-targeting drugs to treat TB.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$111,479 )
2025	2021	THE CHANCELLOR, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	UNIVERSITY OF CAMBRIDGE THE OLD SCHOOLS, TRINITY LANE	CAMBRIDGE				GBR	Allergy and Infectious Diseases Research	000	19	10/1/2024	NON-COMPETING CONTINUATION	-$111,479
														Subtotal = -$111,479

Issue Date FY: 2023 ( Subtotal = -$282,673 )
2023	2021	THE CHANCELLOR, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	UNIVERSITY OF CAMBRIDGE THE OLD SCHOOLS, TRINITY LANE	CAMBRIDGE				GBR	Allergy and Infectious Diseases Research	001	19	5/15/2023	NON-COMPETING CONTINUATION	-$270,000
2023	2020	THE CHANCELLOR, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	UNIVERSITY OF CAMBRIDGE THE OLD SCHOOLS, TRINITY LANE	CAMBRIDGE				GBR	Allergy and Infectious Diseases Research	000	18	5/15/2023	NON-COMPETING CONTINUATION	-$12,673
														Subtotal = -$282,673

Issue Date FY: 2021 ( Subtotal = $270,000 )
2021	2021	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE			GBR	Allergy and Infectious Diseases Research	000	19	6/21/2021	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2020 ( Subtotal = $270,000 )
2020	2020	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	000	18	4/30/2020	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2019 ( Subtotal = $270,000 )
2019	2019	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	000	17	4/10/2019	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2018 ( Subtotal = $270,000 )
2018	2018	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	000	16	4/19/2018	NON-COMPETING CONTINUATION	$270,000
2018	2017	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	002	15	5/2/2018	EXTENSION WITH OR WITHOUT FUNDS	$72,656
2018	2016	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	001	14	5/2/2018	NON-COMPETING CONTINUATION	-$72,656
														Subtotal = $270,000

Issue Date FY: 2017 ( Subtotal = $270,000 )
2017	2017	THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERISTY OF CAMBRIDGE	THE OLD SCHOOLS	CAMBRIDGE	CAMBRIDGESHIRE	CB2 1TN		GBR	Allergy and Infectious Diseases Research	000	15	1/16/2017	EXTENSION WITH OR WITHOUT FUNDS	$270,000
														Subtotal = $270,000

Issue Date FY: 2016 ( Subtotal = $270,000 )
2016	2016	UNIVERSITY OF CAMBRIDGE	The Old Schools,Trinity Lane	CAMBRIDGE				GBR	Allergy and Infectious Diseases Research	000	14	4/30/2016	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2015 ( Subtotal = $230,867 )
2015	2015	UNIVERSITY OF CAMBRIDGE	The Old Schools,Trinity Lane	CAMBRIDGE				GBR	Allergy and Infectious Diseases Research	001	13	6/5/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$270,000
2015	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	002	12	8/7/2015	SUPPLEMENT FOR EXPANSION	$12,073
2015	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	12	6/4/2015	SUPPLEMENT FOR EXPANSION	-$51,206
														Subtotal = $230,867

Issue Date FY: 2014 ( Subtotal = $498,714 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	12	8/21/2014	SUPPLEMENT FOR EXPANSION	$115,875
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	12	4/15/2014	NON-COMPETING CONTINUATION	$382,839
														Subtotal = $498,714

Issue Date FY: 2013 ( Subtotal = $363,075 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	11	4/19/2013	NON-COMPETING CONTINUATION	$347,625
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	11	6/11/2013	NON-COMPETING CONTINUATION	$15,450
														Subtotal = $363,075

Issue Date FY: 2012 ( Subtotal = $386,041 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	10	2/14/2012	COMPETING CONTINUATION	$386,041
														Subtotal = $386,041

Grand Total All Awards = $2,704,544

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Host responses to Mycobacterium infection in Zebrafish.

Award Number: R37AI054503

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2017

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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