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Mild Cognitive Impairment: A Prospective Community Study

Award Number: R37AG023651
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Mild Cognitive Impairment: A Prospective Community Study - Mild Cognitive Impairment: A Prospective Community Study. Dementia is a leading cause of disability and death in older adults. Its incidence increases exponentially with age. Identifying independent risk factors and valid disease markers are critical steps towards prevention, improved diagnosis, and treatment. To enhance clinical and public health care, these factors must be identified in population settings. We seek to extend, for a further five years, a 20-year prospective population-based study of mild cognitive impairment (MCI) and dementia in a low SES-area of southwestern Pennsylvania. The original richly characterized cohort is now aged 85+, and at maximum risk for dementia; we have replenished the cohort and enhanced its ethnoracial diversity by recruiting additional participants from a predominantly African American community. Our objective remains to identify, at the population level, risk factors for clinically relevant adverse cognitive outcomes of MCI, cognitive decline, and progression to dementia. During the current award period we have assessed several plasma biomarkers of Alzheimer's disease and related disorders (ADRD), examined data from ultra-high-resolution (7 Tesla) brain MRI scans on cerebrovascular morphology and gray matter volume including hippocampal segments, and reported preliminary GWAS and RNA sequencing results. We have also examined social determinants of health (SDOH) in relation to MCI. Our aims for the next five years are to build on these discoveries. exploring (1) additional novel plasma ADRD biomarkers, (2) additional 7T brain imaging to examine neural markers of aging including arterial tortuosity and white matter volume, hippocampal volume (whole and subfields), neuroplasticity (synapse/dendrite density), (3) whole genome sequencing to (i) to characterize and fine- map the novel candidate loci identified in GWAS analyses, identify additional and full spectrum of common and low-frequency/rare variants influencing cognitive decline; (ii) to identify novel loci using genome-wide genotype and WGS data for new plasma biomarkers, (iii) to functionally characterize the identified significant variants using genomics and bioinformatics approaches; and (4) to examine the associations of plasma biomarkers, 7T imaging markers, and genomics with one another, and how these markers are distributed by race/ethnicity and by SDOH, using state-of-the-art statistical modeling. RELEVANCE (See instructions): This ongoing population-based epidemiologic study of mild cognitive impairment (MCI) is being conducted among older adults in an under-resourced, ethnoracially diverse, group of communities in a Rust Belt region of Pennsylvania. Our purpose is to identify risk factors for MCI and dementia, and biological markers that predict cognitive decline and progression to dementia, so that steps can be taken to lower these risks.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,831,172 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	003	21	5/21/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	002	21	5/7/2026	EXTENSION WITH OR WITHOUT FUNDS	$3,831,172
2026	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	001	20	4/20/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	20	1/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,831,172

Issue Date FY: 2025 ( Subtotal = $2,671,320 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	20	3/7/2025	NON-COMPETING CONTINUATION	$2,453,253
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	001	20	6/9/2025	NON-COMPETING CONTINUATION	$218,067
														Subtotal = $2,671,320

Issue Date FY: 2024 ( Subtotal = $2,938,462 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	19	4/15/2024	NON-COMPETING CONTINUATION	$2,938,462
														Subtotal = $2,938,462

Issue Date FY: 2023 ( Subtotal = $2,882,221 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	18	2/23/2023	NON-COMPETING CONTINUATION	$2,882,221
														Subtotal = $2,882,221

Issue Date FY: 2022 ( Subtotal = $2,906,516 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	17	5/9/2022	NON-COMPETING CONTINUATION	$2,906,516
														Subtotal = $2,906,516

Issue Date FY: 2021 ( Subtotal = $5,058,266 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	001	16	8/6/2021	COMPETING CONTINUATION	$2,119,309
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Aging Research	000	16	4/27/2021	COMPETING CONTINUATION	$2,938,957
														Subtotal = $5,058,266

Grand Total All Awards = $20,287,957

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Mild Cognitive Impairment: A Prospective Community Study

Award Number: R37AG023651

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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