Sunday, July 6, 2025 7/6/2025

Alcohol and Stress: Interactive Effects

Award Number: R37AA007789
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1988
PERIOD OF PERFORMANCE END DATE: 05/31/2020

Group Awards By:

View Award Description

Alcohol and Stress: Interactive Effects - Depression is often described as a stress-related disorder, as it often occurs in the context of exposure to some form of stress. Indeed, alterations in HPA activity and regulation are one of the most consistently described biological abnormalities in depression and bipolar disorder. Stress can cause remodelling and microdamage in the brain, and can stimulate neuroinflammation. Moreover, significant risk factors for major depressive disorder are associated with increased inflammation; in turn, inflammatory mediators can induce depressive symptoms. In most cases, short-term stress-induced neuroinflammatory activation resolves, and the organism is then resilient in the face of later-life challenges. In the case of an organism with pre-existing vulnerability, such as occurs with PAE, short-term neuroinflammation may fail to resolve, and can progress to a more chronic condition, leaving the organism vulnerable to later life challenge. The present proposal will test the hypothesis that fetal programming of HPA activity by PAE results in altered neuroendocrine- neuroimmune interactions, giving rise to a sensitized, vulnerable organism, with an increased pro- inflammatory bias, that is predisposed to increased responsiveness to stressors or immune challenges later in life, resulting in increased vulnerability to stress-related disorders such as depression and anxiety. This hypothesis will be tested in three Specific Aims: 1) To determine the immediate or short-term effects of PAE and later life stress on depressive-/anxiety-like behavior and behavior mediated by the PFC, as well as markers of stress and neuroimmune function; 2) To examine the long-term effects of PAE and stress in adulthood or adolescence on depressive-/anxiety-like behavior and behavior mediated by the PFC, as well as markers of stress and neuroimmune function; and 3) To investigate the efficacy of antidepressant and anti-inflammatory treatments, separately or in combination, in attenuating or normalizing the adverse effects of PAE and later life stress and/or immune challenges on behavioral, brain, HPA and neuroimmune outcomes. Together, the data from these studies will have important implications for the development of novel therapeutic interventions for depression in individuals with FASD. RELEVANCE (See instructions): The present research utilizes our well-established animal model of prenatal alcohol exposure to examine the role of stress and neuroimmune abnormalities in mediating the increased incidence of depression observed in children with FASD. Our data will significantly increase our understanding of the mechanisms underlying the long-term consequences of prenatal alcohol exposure on health and well-being, and will have important implications for the development of novel therapeutic interventions for depression in individuals with FASD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Alcohol Research Programs	000	29	11/6/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $263,153 )
2018	2018	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	29	5/17/2018	NON-COMPETING CONTINUATION	$263,153
														Subtotal = $263,153

Issue Date FY: 2017 ( Subtotal = $263,153 )
2017	2017	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Alcohol Research Programs	000	28	5/31/2017	NON-COMPETING CONTINUATION	$263,153
														Subtotal = $263,153

Issue Date FY: 2016 ( Subtotal = $269,922 )
2016	2016	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	27	6/15/2016	NON-COMPETING CONTINUATION	$269,922
														Subtotal = $269,922

Issue Date FY: 2015 ( Subtotal = $261,304 )
2015	2015	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	26	5/15/2015	NON-COMPETING CONTINUATION	$261,304
														Subtotal = $261,304

Issue Date FY: 2014 ( Subtotal = $269,691 )
2014	2014	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	25	5/12/2014	EXTENSION WITH OR WITHOUT FUNDS	$269,691
														Subtotal = $269,691

Issue Date FY: 2013 ( Subtotal = $214,052 )
2013	2013	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	24	7/4/2013	EXTENSION WITH OR WITHOUT FUNDS	$214,052
														Subtotal = $214,052

Issue Date FY: 2012 ( Subtotal = $237,102 )
2012	2012	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	23	6/1/2012	NON-COMPETING CONTINUATION	$237,102
														Subtotal = $237,102

Issue Date FY: 2011 ( Subtotal = $243,509 )
2011	2011	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	000	22	6/7/2011	NON-COMPETING CONTINUATION	$243,509
														Subtotal = $243,509

Issue Date FY: 2010 ( Subtotal = $275,235 )
2010	2010	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	001	21	5/14/2010	NON-COMPETING CONTINUATION	$253,635
2010	2010	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Alcohol Research Programs	002	21	6/7/2010	SUPPLEMENT FOR EXPANSION	$21,600
2010	2009	UNIVERSITY OF BRITISH COLUMBIA	**	VANCOUVER, B C		00000		CAN	Alcohol Research Programs	003	20	8/25/2010	COMPETING CONTINUATION	$0
2010	2009	UNIVERSITY OF BRITISH COLUMBIA	**	VANCOUVER, B C		00000		CAN	Alcohol Research Programs	000	20	12/7/2009	COMPETING CONTINUATION	$0
														Subtotal = $275,235

Grand Total All Awards = $2,297,121

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Alcohol and Stress: Interactive Effects

Award Number: R37AA007789

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1988

PERIOD OF PERFORMANCE END DATE: 05/31/2020

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer