Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Probing the Proteome: Depressive Symptoms, Inflammation and Mitochondrial Perturbations in Acute HIV Infection

Award Number: R36MH139364
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2026

Group Awards By:

View Award Description

Probing the Proteome: Depressive Symptoms, Inflammation and Mitochondrial Perturbations in Acute HIV Infection - PROJECT SUMMARY The primary objective of the proposed R36 is to elucidate molecular mechanisms whereby inflammation and mitochondrial dysfunction, both in the presence and absence of amphetamine-type stimulant use during acute HIV infection, can predict persistent depressive symptoms over 96 weeks of suppressive antiretroviral therapy. By 2030, it is expected that the two leading causes of disease around the world will be HIV and depressive disorders, and the excess burden among people with HIV (PWH) is estimated to be three times higher than among those without HIV. During AHI, gut immune dysfunction can lead to the release of proinflammatory cytokines into the periphery. These cytokines can cross the blood brain barrier, leading to damage in the brain and alterations of the functional connectivity of key circuits involved in emotional processes and the hypothalamic-pituitary-adrenal axis stress response associated with depressive symptoms. Several studies have also independently linked mitochondrial stress and depressive symptoms. When stressed, mitochondria activating potent inflammatory cascades, which contribute to the heightened inflammatory state that is often characteristic of AHI. Amphetamine-type stimulant use (ATS) is also known to increase HIV pathogenesis in the central nervous system, contribute to oxidative stress and increase serum biomarkers of inflammation. ATS can also lead to significant changes in the dopamine and glutaminergic systems, both of which are involved in substance use and depression. Taken together, these disturbances can increase oxidative stress and exacerbate neuroinflammation. Therefore, this study proposes to leverage the explanatory strength of proteomics to identify biological signatures underlying distinct trajectories of depression in PWH, by leveraging 100 plasma samples from the RV254/SEARCH010 cohort, the largest prospective investigation of individuals who have undergone extensive clinical phenotyping from acute through chronic HIV. Based on previous characterizations of depressive symptom trajectories over 96 weeks, Aim 1 will determine the associations of proteomic alterations relevant to inflammation and mitochondrial dysfunction of persistent [n=50] (versus resolved [n=50]) depressive symptoms over 96 weeks of suppressive ART. Aim 2 will examine if recent ATS use amplifies the associations of these proteomic alterations with persistent (versus resolved) depressive symptoms over 96 weeks of suppressive ART. Proteomic signatures will be identified using the SomaScan Assay, a highly multiplexed aptamer-based proteomic technology. The depth of the data that will be collected through this study will provide exceptional opportunities to further interrogate neuroimmune mechanisms relevant to persistent depressive symptoms and neurocognitive impairment in a planned K99/R00 proposal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $45,516 )
2026	2026	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	2	12/4/2025	NON-COMPETING CONTINUATION	$45,516
														Subtotal = $45,516

Issue Date FY: 2025 ( Subtotal = $45,516 )
2025	2025	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	1	12/11/2024	NEW	$45,516
														Subtotal = $45,516

Grand Total All Awards = $91,032

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Probing the Proteome: Depressive Symptoms, Inflammation and Mitochondrial Perturbations in Acute HIV Infection

Award Number: R36MH139364

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer