Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Regenerate the lung through a better understanding of development

Award Number: R35HL184263
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2026
PERIOD OF PERFORMANCE END DATE: 01/31/2033

Group Awards By:

View Award Description

Regenerate the lung through a better understanding of development - Summary The inability to maintain epithelial integrity or recover from prolonged injury is closely linked to the development of end-stage lung diseases such as idiopathic pulmonary fibrosis (IPF), which currently lacks effective treatments. The long-term objective of the Que laboratory is to restore epithelial integrity by gaining a comprehensive understanding of how the epithelium develops in embryos and regenerates in adults. We have employed a combination of genetic manipulation, lineage tracing, 3D organoid models, and single-cell RNA sequencing, along with advanced bioinformatics analyses, to demonstrate that developmental signaling pathways and downstream factors, including transcription factors, are re-used during regeneration. For example, we have shown that Wnt signaling molecules (such as Wntless/Gpr177) and transcription factors like Isl1 and Sox9 are critical in both lung development and injury repair. While our lab has highlighted the importance of genetic regulation in epithelial generation and regeneration, recent work has shifted focus to the role of posttranscriptional regulation. Preliminary data suggest that the deletion of posttranscriptional regulators disrupts epithelial progenitor specification and lung development. Further studies indicate that these regulators are also crucial for epithelial regeneration following injury. Additionally, we are exploring the interaction of posttranscriptional regulators with transcription factors in the reprogramming of fibroblasts into alveolar progenitor cells. Our research has led to numerous collaborations, and we will expand these efforts to broaden the impact, particularly in the areas of posttranscriptional regulation in lung generation, regeneration, and reprogramming. The goal of our proposed studies is to deepen our understanding of how the lung epithelium is generated and restored, with the aim of identifying new targets and developing more effective, targeted therapies to reverse end-stage lung diseases such as IPF.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,151,498 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Lung Diseases Research	000	1	3/11/2026	NEW	$1,151,498
														Subtotal = $1,151,498

Grand Total All Awards = $1,151,498

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Regenerate the lung through a better understanding of development

Award Number: R35HL184263

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2026

PERIOD OF PERFORMANCE END DATE: 01/31/2033

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer