Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Visualizing Sodium in Lymphatic Disease: a Translational Path

Award Number: R35HL184172
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2033

Group Awards By:

View Award Description

Visualizing Sodium in Lymphatic Disease: a Translational Path - ABSTRACT The long-term goal of this research program is to reduce lymphatic disease burden through translational magnetic resonance imaging (MRI). We have developed a noninvasive multi-nuclear 23Na/1H MRI approach to visualize the lymphatic system together with sodium and adipose tissue storage in humans called Sodium, Adipose, and Lymphatics Translational (SALT) MRI. In prior studies by the research team, SALT MRI demonstrated tissue sodium accumulation in human lymphatic disease for the first time in leg lymphedema (R01HL155523) and lipedema (R01HL157378). These discoveries open new questions about the lymphatic physiology of tissue sodium clearance in humans, as well as methods to image this physiology which we will pursue during the R35 program. The translational research goals of our R35 research program are to: (T2, Translation in Patients with Leg Lymphedema) understand disease progression of leg lymphedema and sodium response to micro-surgical repair, (T1, Technology Development for Imaging Arm Lymphedema) build MRI technologies to observe sodium and lymphatic physiology in arm lymphedema, and (T0, Basic Science of Lipedema) discover disease mechanisms of sodium storage in lipedema. Research goals are expected to develop imaging biomarkers of leg lymphedema progression and treatment, open new avenues of investigation in arm lymphedema, and could reveal new diagnostic strategies for lipedema which are desperately needed to reduce the time to diagnosis. Overall, these studies will prepare imaging outcome measures for emerging clinical trials in lymphatic disease. We are committed to developing translational imaging to meet clinical unmet needs for patients with lymphatic disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $950,550 )
2026	2026	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Cardiovascular Diseases Research	000	1	3/16/2026	NEW	$950,550
														Subtotal = $950,550

Grand Total All Awards = $950,550

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Visualizing Sodium in Lymphatic Disease: a Translational Path

Award Number: R35HL184172

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2033

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer