Wednesday, July 2, 2025 7/2/2025

CD4+ T cell Immunity in the Respiratory Tract

Award Number: R35HL177381
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/05/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2032

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CD4+ T cell Immunity in the Respiratory Tract - Abstract Pneumonia remains the #1 killer of children in the world and is a leading cause of morbidity and mortality in children in the US and the #8 cause of mortality in adults. Our laboratory has made seminal insights in mechanisms underlying host defense against extracelluar pathogens – particularly in the area of type 17 cytokines –IL-17 and IL-22, and tissue resident memory CD4+ T cells. Using murine and primate respiratory tract samples we will assess the metabolic requirement of lung and nasal TRM cells and investigate if antigen exposure is required for lung term survival. We have previously shown these cells occupy a unique submucosal niche and require IL-17RC signaling in fibroblasts for function. We will determine if there are feedback loops between fibroblasts and T cell to maintain these cells and if lung TRM cells epigenetically modify lung fibroblast populations. The research proposed under this R35 will shed new light on pulmonary host defenses that can be exploited to reduce the global burden of pneumonia mortality and morbidity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,063,324 )
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Lung Diseases Research	000	1	6/5/2025	NEW	$1,063,324
														Subtotal = $1,063,324

Grand Total All Awards = $1,063,324

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CD4+ T cell Immunity in the Respiratory Tract

Award Number: R35HL177381

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/05/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2032

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