Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Immune perception of bacterial pathogens in plants

Award Number: R35GM136402
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2030

Group Awards By:

View Award Description

Immune perception of bacterial pathogens in plants - PROJECT SUMMARY/ABSTRACT The research in this proposal centers on how plants detect and respond to bacterial pathogens through their immune system. Plants are equipped with a complex innate immune system, consisting of genetically encoded immune receptors that can identify various pathogens. These receptors bear structural resemblance to those in animals and include both surface-bound pattern recognition receptors (PRRs) and internal nucleotide-binding leucine-rich repeat (NLR) receptors. Plant PRRs, which are either receptor-like kinases or proteins, can detect conserved pathogen or damage-associated molecular patterns (PAMPs/DAMPs). NLR receptors can identify a range of pathogen effector proteins that invade plant cells during infection, leading to programmed cell death at the infection site. Our research will delve into the spatial organization of immune responses, the specificity of immune receptors, and how pathogen variation affects PRR detection. We aim to understand the role of cell death in releasing DAMPs to hinder pathogen spread at the site of infection. Additionally, we will explore how PRR recognition specificity and signaling are regulated, using natural variation as a reference. Our investigation will also cover the effects of variation in pathogen epitopes on immune signaling and PAMP functionality. Through this project, we aim to train emerging scientists and achieve breakthroughs that deepen our comprehension of how initial pathogen detection signals are integrated into an effective defense strategy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $460,192 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	7	3/4/2026	NON-COMPETING CONTINUATION	$460,192
														Subtotal = $460,192

Issue Date FY: 2025 ( Subtotal = $460,512 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	001	6	1/21/2025	COMPETING CONTINUATION	$460,512
2025	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	5	11/8/2024	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	002	5	6/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $460,512

Issue Date FY: 2024 ( Subtotal = $510,701 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	003	5	5/16/2024	NON-COMPETING CONTINUATION	$39,249
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	4	12/20/2023	SUPPLEMENT FOR EXPANSION	$29,474
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	001	5	2/8/2024	NON-COMPETING CONTINUATION	$353,251
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	002	5	2/13/2024	SUPPLEMENT FOR EXPANSION	$88,727
														Subtotal = $510,701

Issue Date FY: 2023 ( Subtotal = $392,500 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	4	2/8/2023	NON-COMPETING CONTINUATION	$392,500
														Subtotal = $392,500

Issue Date FY: 2022 ( Subtotal = $392,500 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	3	2/11/2022	NON-COMPETING CONTINUATION	$353,250
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	001	3	6/22/2022	NON-COMPETING CONTINUATION	$39,250
														Subtotal = $392,500

Issue Date FY: 2021 ( Subtotal = $392,500 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	2	2/9/2021	NON-COMPETING CONTINUATION	$392,500
														Subtotal = $392,500

Issue Date FY: 2020 ( Subtotal = $392,500 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Biomedical Research and Research Training	000	1	3/27/2020	NEW	$392,500
														Subtotal = $392,500

Grand Total All Awards = $3,001,405

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Immune perception of bacterial pathogens in plants

Award Number: R35GM136402

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer