Thursday, November 21, 2024 11/21/2024

Improving Survival in Oral Cancer by Disruption of Tumor Progression

Award Number: R35DE027551
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT/ PROJECT SUMMARY Invasion is required for development and spread of head and neck cancer (HNC) but unfortunately there are no strategies that effectively target invasion. This knowledge gap is due to limited progress in identifying and understanding the underlying mechanisms that control invasion. While progress has been made in establishing that epithelial to mesenchymal transition in HNC cells allows them to spread and become resistant to treatment, critical mechanistic links are unknown. It is also unclear which tumors will spread and become resistant to treatment. Given the continued poor survival of patients with HNC, this project will address the following questions: 1) what are the mechanisms that encourage HNC to spread; 2) how is HNC protected from radiation and who is at risk for developing resistance; and 3) how does HNC recur. This work will provide the foundation for novel mechanism-based treatment strategies to improve the survival of patients with HNC.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	8	11/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $993,500 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	8	6/11/2024	NON-COMPETING CONTINUATION	$993,500
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	7	11/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $993,500

Issue Date FY: 2023 ( Subtotal = $1,013,830 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	7	6/2/2023	NON-COMPETING CONTINUATION	$1,013,830
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	6	1/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,013,830

Issue Date FY: 2022 ( Subtotal = $1,001,292 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	6	5/31/2022	NON-COMPETING CONTINUATION	$1,001,292
2022	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	5	12/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,001,292

Issue Date FY: 2021 ( Subtotal = $1,013,126 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	5	5/13/2021	NON-COMPETING CONTINUATION	$1,013,126
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	4	11/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,013,126

Issue Date FY: 2020 ( Subtotal = $1,009,712 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	4	5/28/2020	NON-COMPETING CONTINUATION	$1,009,712
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	2/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,009,712

Issue Date FY: 2019 ( Subtotal = $1,007,799 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	3	6/6/2019	NON-COMPETING CONTINUATION	$1,007,799
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	2	2/1/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,007,799

Issue Date FY: 2018 ( Subtotal = $1,009,811 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	2	6/20/2018	NON-COMPETING CONTINUATION	$1,009,811
														Subtotal = $1,009,811

Issue Date FY: 2017 ( Subtotal = $1,007,016 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	1	9/14/2017	NEW	$1,007,016
														Subtotal = $1,007,016

Grand Total All Awards = $8,056,086

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Improving Survival in Oral Cancer by Disruption of Tumor Progression

Award Number: R35DE027551

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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