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SPIRIT: A Culturally Grounded Supportive Care Intervention for Chickasaw Nation Patients with Cancer

Award Number: R34NR022364
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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SPIRIT: A Culturally Grounded Supportive Care Intervention for Chickasaw Nation Patients with Cancer - Project Summary/Abstract Our long-term goal is to enhance cancer care delivery and outcomes for First Americans. The objective of this application is to develop and pilot a supportive care intervention called SPIRIT (Supportive Palliative Intervention Respecting Indigenous Traditions) that addresses the culturally informed care needs and concerns of First American patients with cancer. SPIRIT is a collaboration between the Chickasaw Nation and the Stephenson Cancer Center (SCC), an NCI-designated cancer center, at the University of Oklahoma (OU) Health. Our team has a long-standing and successful history of collaborative research to enhance care for First Americans with cancer, including with the Chickasaw Nation Department of Health (CNDH), which is one of the largest tribally operated health systems in the US. CNDH is a predominately rural tribal healthcare system that, like many tribal health systems, refers patients with cancer to specialists located in urban areas. These outside specialists may not understand the nuances of the CNDH referral processes nor these patients’ Indigenous knowledge and values. Thus, interventions to streamline cancer care coordination across CNDH and the SCC are urgently needed, particularly with regards to the unique supportive care needs of First Americans. SPIRIT builds on a strong tribal-academic partnership, which fosters the co-development of a culturally informed supportive care intervention for First American patients with cancer. The intervention integrates established evidence from the supportive and palliative care literature, facilitated by our team’s experts in palliative care and supportive oncology, to ensure both clinical rigor and cultural responsiveness. Importantly, a community advisory board of patients with cancer and staff from CNDH and SCC will guide SPIRIT’s refinement and implementation in collaboration with the tribal health system. With input from the community advisory board and key informants, the intervention will entail patient navigation, symptom monitoring, collaborative care, and personalized palliative care. We will conduct an open pilot (n=20) to demonstrate the feasibility and acceptability of delivering the SPIRIT intervention for First American patients with cancer. Our hypothesis is that by developing a culturally informed supportive care intervention, we can feasibly deliver an intervention that addresses the unique needs of First American patients with cancer. We aim to 1) develop the SPIRIT intervention to provide patient navigation, foster proactive symptom monitoring, ensure collaborative care, and personalize palliative care for First American patients with cancer, 2) assess feasibility and acceptability of delivering SPIRIT for First American patients with cancer (n=20), and 3) identify facilitators and barriers to implementation of the SPIRIT intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $653,357 )
2026	2026	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 560	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Nursing Research	000	1	9/2/2026	NEW	$653,357
														Subtotal = $653,357

Grand Total All Awards = $653,357

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SPIRIT: A Culturally Grounded Supportive Care Intervention for Chickasaw Nation Patients with Cancer

Award Number: R34NR022364

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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