Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)

Award Number: R34MH130562
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE) - Project Abstract. Insomnia disorder impacts one in two women by the end of their 3rd trimester, and half of pregnant women with insomnia endorse comorbid depression. Though cognitive-behavioral therapy for insomnia (CBTI) has efficacy in pregnancy, CBTI produces smaller effects on insomnia and depression as compared to non-perinatal patients. Our team has identified a promising candidate factor that predicts suboptimal response to insomnia therapy: high cognitive arousal, a transdiagnostic phenomenon of heightened cognitive activity, particularly in the form of perseverative thinking (worry, rumination). Nearly all pregnant women with insomnia have high cognitive arousal before insomnia therapy, but CBTI produces minimal effect on these symptoms. Pregnant women with high cognitive arousal after insomnia therapy are 4 times LESS likely to remit from insomnia, and 3 times MORE likely to have depression relative to women whose arousal decreases with therapy. In effort to enhance alleviation of cognitive arousal to optimize clinical outcomes, we placed efficacious behavioral sleep strategies within a mindfulness intervention framework to develop an insomnia therapy specifically for pregnant women: Perinatal Understanding of Mindful Awareness for Sleep (PUMAS). Unlike CBTI, efficacy data show that PUMAS produces large reductions in insomnia, depression, and cognitive arousal relative to control. Moreover, efficacy data suggest that reducing cognitive arousal may represent a mechanism by which PUMAS reduces insomnia and depression. The next step in the NIMH phase of intervention development is to translate these efficacy data into real-world practice. Evaluating the acceptability, feasibility, and preliminary effectiveness of PUMAS implemented in real-world clinics is absolutely critical and has immense potential to reduce burden of maternal mental illness. Aligned with NIMH emphasis on experimental therapeutics approach, we will investigate reductions in cognitive arousal as a key mechanism by which PUMAS alleviates insomnia and depression. We propose an effectiveness-implementation hybrid type 1 pilot RCT wherein 100 pregnant women with DSM-5 insomnia disorder are randomized to telemedicine PUMAS or sham therapy control. We will implement PUMAS in all 23 women’s health clinics across Henry Ford Health System, centrally located in Metro Detroit. Implementation will reflect real-world clinic operations such that women receiving prenatal care who report sleep difficulties will be referred by OB physicians and midwifes to therapists embedded in the women’s health clinics for evaluation and treatment. After treatment, we will assess participants across the first postpartum year to preliminarily evaluate the durability of clinical outcomes. This project will not only test PUMAS preliminary effectiveness for insomnia and depression, but will also investigate whether PUMAS engages a key candidate mechanism (high cognitive arousal) that is operative for alleviating these clinical outcomes in the effectiveness context (PAR-21-131).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Mental Health Research Grants	000	3	5/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $167,705 )
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Mental Health Research Grants	000	3	6/5/2024	NON-COMPETING CONTINUATION	$167,705
														Subtotal = $167,705

Issue Date FY: 2023 ( Subtotal = $281,247 )
2023	2023	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Mental Health Research Grants	000	2	8/10/2023	NON-COMPETING CONTINUATION	$281,247
														Subtotal = $281,247

Issue Date FY: 2022 ( Subtotal = $280,802 )
2022	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Mental Health Research Grants	000	1	8/23/2022	NEW	$280,802
														Subtotal = $280,802

Grand Total All Awards = $729,754

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)

Award Number: R34MH130562

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer