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Evaluating the Feasibility and Acceptability of "PrEP-Talk": A PrEP Uptake Intervention for Young Black MSM with their Close Friends

Award Number: R34MH118122
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary Young Black MSM (YBMSM) are at critically high and disproportionate HIV risk. Reducing HIV incidence rates among YBMSM will likely require increased adoption of additional strategies such as pre-exposure prophylaxis (PrEP). PrEP is a FDA approved medication for HIV that also prevents HIV transmission when taken appropriately. Interventions are needed to address potential individual, social/cultural, and structural barriers to uptake and adherence of PrEP among YBMSM to help curb HIV infections. Our preliminary research suggests that some YBMSM feel concerned that PrEP is not effective or may be toxic, about being stigmatized for having HIV if they take PrEP, as well as concerns about access and side effects. Therefore, we propose “PrEP-Talk”, an intervention that will use a PrEP Counselor (PC) who can provide information and guidance to YBMSM with the inclusion of a close friend (CF) to support PrEP uptake and adherence. In order to address these critical and timely issues, we developed the following specific aims: 1. To develop and manualize “PrEP-Talk,” which aims to increase PrEP uptake and adherence among YBMSM. This will be done through qualitative formative research (3 focus groups with 12-18 YBMSM and CF dyads, N=24-36); partnering with a community advisory board (comprised of individuals knowledgeable about HIV work with YBMSM); and field tests of the intervention with 5 YBMSM and CF dyads (N=10). 2. Examine feasibility, acceptability and indicators of preliminary efficacy of “PrEP- Talk” on PrEP uptake and adherence among YBMSM. This will be accomplished through a pilot randomized controlled trial (RCT) with 30 dyads (YBMSM and CFs) in the intervention and 30 dyads in the control (N=120). We will conduct assessments at baseline, 3-months and 6-months post-baseline. We will also assess PrEP uptake supportive communication at each intervention session and collect urine samples to measure a biomarker of PrEP uptake (initial adherence) from all YBMSM who report use of PrEP. This proposed study is significant because our intervention may increase PrEP uptake and adherence, which may help to reduce HIV incidence among YBMSM. If the proposed intervention shows promise, we will prepare to undertake a full-scale R01-funded RCT.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$7,012 )
2024	2021	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Mental Health Research Grants	000	3	12/22/2023	NON-COMPETING CONTINUATION	-$7,012
														Subtotal = -$7,012

Issue Date FY: 2021 ( Subtotal = $187,040 )
2021	2021	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Mental Health Research Grants	000	3	4/13/2021	NON-COMPETING CONTINUATION	$187,040
														Subtotal = $187,040

Issue Date FY: 2020 ( Subtotal = $231,081 )
2020	2020	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Mental Health Research Grants	000	2	3/25/2020	NON-COMPETING CONTINUATION	$231,081
														Subtotal = $231,081

Issue Date FY: 2019 ( Subtotal = $238,422 )
2019	2019	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Mental Health Research Grants	000	1	5/20/2019	NEW	$238,422
														Subtotal = $238,422

Grand Total All Awards = $649,531

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Evaluating the Feasibility and Acceptability of "PrEP-Talk": A PrEP Uptake Intervention for Young Black MSM with their Close Friends

Award Number: R34MH118122

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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