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Multisite feasibility of BA-HD: An integrated depression and behavioral risk factor reduction coaching program following acute coronary syndrome

Award Number: R34HL165716
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Multisite feasibility of BA-HD: An integrated depression and behavioral risk factor reduction coaching program following acute coronary syndrome - PROJECT ABSTRACT Acute coronary syndrome (ACS) is an urgent public health issue which contributes to over one million hospitalizations annually. Depression undermines optimal recovery following ACS, often at least partially through interference with health behaviors. Post-ACS patients with depression smoke more, adhere to medications less often, are less physically active, and have poorer diet than post-ACS patients without depression. This reduced adherence to recommended health behaviors, in turn, worsens cardiovascular health and increases risk of additional morbidity and mortality. Our team developed Behavioral Activation for Health and Depression (BA-HD) which is a behavioral activation-based intervention that integrates treatment for depression and multiple health behavior change post-ACS. The overarching goal of this R34 application is to pilot BA-HD across three distinct regions (Northeast, Midwest, and Southeast) in preparation for a subsequent fully powered multisite randomized controlled efficacy trial. Specifically, the research team will conduct a multisite pilot randomized controlled feasibility trial of BA-HD comparing the intervention to an Enhanced Usual Care (EUC) control group. This trial will accomplish two aims: First, we will examine study feasibility (e.g., recruitment, treatment engagement, retention) and acceptability of both study procedures and the BA-HD treatment. Second, we will examine the preliminary efficacy of BA-HD to improve (1) depressed mood and (2) cardiovascular health assessed via the American Heart Association’s Life’s Simple 7 Total Score. Findings from the proposed research are necessary to finalize study design in preparation for a subsequent fully powered trial to evaluate the efficacy of BA-HD to improve cardiovascular health and depression


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Cardiovascular Diseases Research	000	2	12/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Cardiovascular Diseases Research	000	2	7/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $327,252 )
2024	2024	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Cardiovascular Diseases Research	000	2	7/11/2024	NON-COMPETING CONTINUATION	$327,252
														Subtotal = $327,252

Issue Date FY: 2023 ( Subtotal = $354,251 )
2023	2023	THE MIRIAM HOSPITAL	164 SUMMIT AVE	PROVIDENCE	RI	02906	PROVIDENCE	USA	Cardiovascular Diseases Research	000	1	8/10/2023	NEW	$354,251
														Subtotal = $354,251

Grand Total All Awards = $681,503

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Multisite feasibility of BA-HD: An integrated depression and behavioral risk factor reduction coaching program following acute coronary syndrome

Award Number: R34HL165716

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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