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PrEP-RISE: A Multi-Level PhotoVoice Intervention to Improve PrEP Uptake and Adherence Among Women Who Inject Drugs (WWID)

Award Number: R34DA064469
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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PrEP-RISE: A Multi-Level PhotoVoice Intervention to Improve PrEP Uptake and Adherence Among Women Who Inject Drugs (WWID) - Women who inject drugs (WWID) in the United States experience disproportionately high rates of HIV due to vulnerabilities related to drug use and sex. Despite the proven effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV, its uptake among WWID remains critically low, in part due to mistrust and negative perceptions about the healthcare system among this population. This project introduces PrEP-RISE, a multi-level intervention designed to improve PrEP uptake and persistence among WWID by addressing hesitations about medication and negative attitudes toward this population. Building on our previous research and leveraging the participatory method of Photovoice (PV), the intervention integrates targeted PrEP education during PV sessions to empower WWID, build trust, and provide warm handoffs to same-day PrEP care at non-traditional healthcare settings. Negative perceptions about WWID will be addressed through PV exhibitions showcasing participants' experiences and suggestions for change, fostering dialogue and empathy among key stakeholders, such as healthcare providers and law enforcement. Guided by the Situated Information-Motivation-Behavioral Skills (slMB) model and intervention development frameworks (ORBIT, 6SQulD), this study will refine and evaluate PrEP-RISE through an exploratory randomized controlled trial involving 116 WWID and 100 community members. The study will assess feasibility, acceptability, and preliminary efficacy in increasing PrEP uptake and persistence among WWID and measure any change in attitudes about this population among community members. This R34 proposal aligns with NIDA priorities to reduce HIV rates and improve health outcomes for high-risk groups, while contributing to the evidence base for multi-level, participatory interventions in real-world settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $256,165 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	5/19/2026	NEW	$256,165
														Subtotal = $256,165

Grand Total All Awards = $256,165

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PrEP-RISE: A Multi-Level PhotoVoice Intervention to Improve PrEP Uptake and Adherence Among Women Who Inject Drugs (WWID)

Award Number: R34DA064469

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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