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An Integrated HIV/OEND Peer Navigation Intervention for Latinx People Who Use and Sell Drugs (PWUSD)

Award Number: R34DA063431
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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An Integrated HIV/OEND Peer Navigation Intervention for Latinx People Who Use and Sell Drugs (PWUSD) - Drug overdoses, HIV transmission, and other substance use-related co-morbidities are soaring among people who use drugs (PWUD) in the US. Among the demographic sectors who continue to be overlooked by risk reduction programming, one key population is comprised of people who use and sell drugs (PWUSD). People who sell drugs are not typically engaged by public health interventions and have limited access to health services despite often suffering from substance use disorder (SUD) themselves. This R34 study seeks to address health disparities to accessing HIV, overdose prevention, and other public health services by developing and piloting an integrated HIV/overdose education and naloxone distribution (OEND) peer navigation intervention targeting PWUSD in Kensington, Philadelphia. The proposed pilot intervention will train 45 PWUSD in the use and distribution of naloxone and will link them to PrEP via peer navigation. In neighborhoods with large, open-air narcotics markets such as Kensington, PWUSD are strategic participants because they are the only group who interact continuously with other people who sell drugs, PWUD, and surrounding local residents who do not participate in the narcotics economy. They interact sexually with all these populations and also often use drugs and are at risk of HIV. Research by the investigative team has shown that Kensington drug suppliers are part of demographic groups who also control most of the largest retail drug markets in the US Northeast, mid-Atlantic, and Rustbelt regions in addition to Southern California and the Southwest/Mexican borderlands. Incorporating these PWUSD into health services programming consequently may considerably expand access to risk reduction services in the US, transforming narcotics retail endpoints into sites of opportunity for public health intervention. In this pilot study, we will randomize 90 HIV-negative PWUSD (20% female) to a 4-session experimental arm with peer navigation to PrEP or a time- and attention-controlled standard HIV/OEND one-session training and follow them for 12 weeks. The study will assess whether receiving peer navigation to PrEP and peer training on naloxone significantly improves health outcomes among participating PWUSD compared to receiving basic training on locally-available services alone. The primary outcomes are: (1) PrEP uptake and adherence and (2) increased carrying of naloxone and naloxone competency. The study’s findings will inform an R01 application for a full-scale efficacy trial testing this intervention at a larger scale, and will have implications for research with PWUSD throughout the United States.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	11/20/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $753,286 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	8/12/2025	NEW	$753,286
														Subtotal = $753,286

Grand Total All Awards = $753,286

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An Integrated HIV/OEND Peer Navigation Intervention for Latinx People Who Use and Sell Drugs (PWUSD)

Award Number: R34DA063431

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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