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Nurse-Led Rapid Initiation of HIV Pre-Exposure Prophylaxis Care Among Incarcerated Individuals with Continuation of Care Services Post-Incarceration

Award Number: R34DA061656
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Nurse-Led Rapid Initiation of HIV Pre-Exposure Prophylaxis Care Among Incarcerated Individuals with Continuation of Care Services Post-Incarceration - Incarcerated individuals are at heightened risk for HIV acquisition. HIV pre-exposure prophylaxis (PrEP) is a highly effective preventive measure that is significantly underutilized by this group. The period of incarceration presents a structured environment to identify those at higher risk of HIV exposure, initiate PrEP, and provide continuity of care following release. Recognizing the limited duration and unpredictable nature of incarceration, as well as the constrained availability of prescribing providers, we propose a nurse-led, same-day PrEP initiation model. This approach is aligned with current CDC guidelines and aims to increase PrEP uptake during incarceration. Post-release, participants will be offered a structured follow-up system to support continuation of care. The long-term goal is to develop a scalable PrEP initiation and follow-up intervention. The present proposal seeks to finalize intervention materials, clinical protocols, and an implementation plan for a nurse-led, same-day PrEP initiation intervention with continuation of care after incarceration. The intervention will be tested through a preliminary randomized controlled trial (RCT) in which participants will receive the nurse-led PrEP uptake intervention and access to same-day PrEP initiation and a 30-day supply of PrEP upon release from incarceration. Then, participants will be randomized to receive continuation of care services upon release (NAV) or to a control condition that approximates standard-of-care (SOC) in a 2:1 (NAV:SOC) ratio. Baseline and follow-up interviews will be conducted at 1, 3, and 6 months. The primary outcome is linkage to follow-up care, defined as obtaining a PrEP prescription within six months of release, verified through medical records. The findings will inform the feasibility, acceptability, and preliminary efficacy of this approach, which may serve as a guide for other carceral settings seeking to implement evidence-based, HIV prevention programs. The Rhode Island Department of Corrections (RIDOC) is a site well-suited to conduct this study due to its existing infrastructure and provision of PrEP as part of routine standard of care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $286,642 )
2026	2026	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Drug Use and Addiction Research Programs	001	2	4/28/2026	NON-COMPETING CONTINUATION	$286,642
2026	2025	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Drug Use and Addiction Research Programs	000	1	1/29/2026	NEW	$0
														Subtotal = $286,642

Issue Date FY: 2025 ( Subtotal = $286,660 )
2025	2025	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Drug Use and Addiction Research Programs	000	1	7/30/2025	NEW	$286,660
														Subtotal = $286,660

Grand Total All Awards = $573,302

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Nurse-Led Rapid Initiation of HIV Pre-Exposure Prophylaxis Care Among Incarcerated Individuals with Continuation of Care Services Post-Incarceration

Award Number: R34DA061656

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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