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Developing an Empowerment Theory-Based Smoking Cessation Intervention for People with High Levels of Social Stress

Award Number: R34DA060534
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2024
PERIOD OF PERFORMANCE END DATE: 08/02/2025
AWARD TERMINATION DATE: 12/05/2025

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Developing an Empowerment Theory-Based Smoking Cessation Intervention for People with High Levels of Social Stress - This multi-phased, community-engaged R34 proposal was developed with community partners to (1) inform, (2) develop, and (3) pilot test protocol for ECHO (Empowering Our Community & Health Outcomes), a smoking cessation intervention tailored for people experiencing high levels of social stress, an established risk factor for nicotine dependence and cessation relapse. The proposed work qualifies as “Stage I (treatment generation, refinement)” in “the development and testing of behavioral and integrative treatments for substance use and dependence” as per PAR- 22-183. Tobacco use is still a leading preventable cause of disease and death in the U.S. and current cessation treatments have limited success; two-thirds relapse within 6 months of a quit attempt. Existing smoking cessation interventions overwhelmingly focus on within-person processes of behavior change rather than addressing key socioenvironmental factors of cessation success. Our innovative approach, grounded in Empowerment Theory (ET), posits that when people participate in community-serving volunteer activities while making a quit smoking attempt, they may also experience cognitive and behavioral improvements (i.e., enhanced stress coping, social support, self-worth, prosociality) that ameliorate socioenvironmental stressors, thereby increasing cessation success. ET-informed health behavior change approaches have worked for infectious disease prevention and youth tobacco interventions, suggesting that ET may also enhance smoking cessation for people with high levels of social stress. Our pretest of ECHO in Oklahoma (OK; N=20) demonstrated strong feasibility and acceptability for an additive intervention design wherein participants received remotely-delivered standard smoking cessation assistance and did volunteer activities. Building on this work, we propose to: (Aim 1/Phase 1) Prioritize key factors that support smoking cessation success among people with high levels of social stress using ecological momentary assessment (EMA) of active smoking cessation quit attempts with n=60 nationally-recruited adults; (Aim 2/Phase 2) Use a rapid, iterative design process with our community partners in OK and the San Joaquin Valley (SJV), California to develop volunteer activity protocols likely to maximize factors supporting cessation success with n=12 adults with high levels of social stress who are ready to quit smoking; and (Aim 3/Phase 3) Use the volunteer activity protocols developed in Aim 2 to conduct a pilot randomized controlled trial (RCT) of the ECHO intervention with our community partners and n=50 adults with high levels of social stress who are ready to quit smoking in OK and the SJV. Conducted remotely to increase scalability and accessibility, this project lays the groundwork of a future R01 application for a fully-powered, multi-site RCT of ECHO to improve cessation outcomes across the country.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$231,626 )
2026	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 560	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	001	2	3/2/2026	TERMINATION	-$9,399
2026	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	000	2	12/5/2025	TERMINATION	-$222,227
														Subtotal = -$231,626

Issue Date FY: 2025 ( Subtotal = $222,227 )
2025	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	001	2	8/8/2025	NON-COMPETING CONTINUATION	$222,227
2025	2024	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	000	1	10/24/2024	NEW	$0
														Subtotal = $222,227

Issue Date FY: 2024 ( Subtotal = $191,251 )
2024	2024	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	000	1	9/6/2024	NEW	$191,251
														Subtotal = $191,251

Grand Total All Awards = $181,852

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Developing an Empowerment Theory-Based Smoking Cessation Intervention for People with High Levels of Social Stress

Award Number: R34DA060534

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2024

PERIOD OF PERFORMANCE END DATE: 08/02/2025

AWARD TERMINATION DATE: 12/05/2025

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