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Transformative Optical Imaging of Brain & Behavior in Navigating Genetic Species

Award Number: R34DA059500
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Transformative Optical Imaging of Brain & Behavior in Navigating Genetic Species - PROJECT SUMMARY / ABSTRACT Our long-term goal is to define general principles that connect neuronal activity to unconstrained behaviors in natural sensory environments. Achieving this goal will require the development of new tools to quantitatively compare behavior across species in complex environments and to monitor neural activity in freely moving an- imals. Here we propose to bring together a diverse, multi-disciplinary team of five labs with a track record of productively measuring and modeling neural activity and behavior. We will use two parallel approaches to make progress towards imaging neural activity from freely moving small genetic model organisms as they navigate complex sensory environments. In Aim 1 we will develop behavioral apparatus that allows for experimenter control of sensory stimuli (mechanosensory flow, odor, and visual stimuli) while monitoring unconstrained be- havior at two resolutions. Low resolution measurements allow for quantification of stimulus-guided navigation, while high resolution measurements allow for detailed quantification of body posture and limb kinematics, and will eventually permit imaging of neural activity. In Aim 2, we will develop bioluminescence-based transgenic animals and techniques for imaging neural activity in freely moving flies and fish. Optimization of these reagents and protocols will allow for eventual simultaneous measurements of neural activity and behavior in larger and more complex environments. This work draws on our collective expertise in quantitative behavior, biolumines- cent indicators, real-time tracking of animal behavior at high resolution, and physical modeling of animal behav- ior. This work will advance technologies for studying neural activity in unconstrained animals and establish a collaborative team to pursue this work.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $349,975 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Drug Use and Addiction Research Programs	000	2	3/6/2025	NON-COMPETING CONTINUATION	$349,975
														Subtotal = $349,975

Issue Date FY: 2024 ( Subtotal = $402,100 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	3/15/2024	NEW	$402,100
														Subtotal = $402,100

Grand Total All Awards = $752,075

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Transformative Optical Imaging of Brain & Behavior in Navigating Genetic Species

Award Number: R34DA059500

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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