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Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders among Adolescents with SUD

Award Number: R34DA056026
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders among Adolescents with SUD - Project Summary (Abstract) This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents (age 13-21) enrolled in usual care for substance use problems. Internalizing disorders (IDs), primarily depression and anxiety, are highly prevalent among youth receiving community-based treatment for substance use disorders (SUDs), and unresolved ID issues significantly interfere with SUD treatment and recovery processes. Yet, the youth SUD clinical workforce is not systematically educated or trained in evidence-based practices for ID; thus, line services for youth SUD do not systematically target IDs. The research literature offers a few integrated behavioral models for simultaneously treating both SUDs and IDs in youth; however, such models feature intensive manualized procedures that have proven cumbersome to scale and deliver in frontline settings. As a result, the clinical workforce, though desiring ID-focused training, currently has inadequate resources for treating IDs effectively. A promising solution to reduce this quality gap is developing a modular, family-based protocol to augment routine care for comorbid SUD/ID by directly targeting ID as a primary treatment goal: Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID). Fam-AID will contain six modules designed to enhance existing SUD services and to be delivered in any sequence to meet client needs: (1) Family Engagement of caregivers in treatment planning and services; (2) Relational Reframing of family constraints, resiliencies, and social capital connected to the youth's ID symptoms; (3) Functional Analysis of the youth's ID symptoms and related behaviors; (4) Core cognitive-behavioral treatment techniques to address the youth's ID symptoms and functional needs, featuring transdiagnostic interventions (emotion acceptance, emotional exposure, behavioral activation) to address negative affect and emotional dysregulation underlying both depression and anxiety; (5) Family Psychoeducation and Safety Planning focused on education about comorbid SUD/ID and prevention of youth self-harm. The study will follow the NIDA blueprint for Stage 1 development of behavioral protocols. In the Pilot Stage we will use rapid cycle prototyping methods in collaboration with end-user stakeholders at two Pilot sites to: (1) Draft protocol delivery and fidelity guidelines adapted from existing study team resources; (2) Solicit clinic staff and client input on protocol content and delivery via cognitive interviewing; (3) Pilot the prototype components on 2-3 cases at each site. We will then conduct an Interrupted Time Series Study for N = 60 comorbid SUD/ID cases across two sites serving diverse youth: 30 will receive TAU (historical control), and then following line staff training in the protocol, 30 new cases will receive TAU enhanced by Fam- AID. Aim 1 will examine Fam-AID cases for protocol acceptability via therapist and client interviews and fidelity benchmarks via therapist- and observer-report protocol fidelity data. Aim 2 will compare Fam-AID versus TAU for immediate outcomes on family attendance in sessions and ultimate outcomes on youth ID symptoms at Baseline, 3-, and 6-month follow-up.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $243,397 )
2026	2026	PARTNERSHIP TO END ADDICTION	711 3RD AVE RM 500	NEW YORK	NY	10017	NEW YORK	USA	Drug Use and Addiction Research Programs	000	3	3/19/2026	NON-COMPETING CONTINUATION	$243,397
														Subtotal = $243,397

Issue Date FY: 2025 ( Subtotal = $243,353 )
2025	2025	PARTNERSHIP TO END ADDICTION	711 3RD AVE RM 500	NEW YORK	NY	10017	NEW YORK	USA	Drug Use and Addiction Research Programs	001	2	4/4/2025	NON-COMPETING CONTINUATION	$243,353
2025	2024	PARTNERSHIP TO END ADDICTION	711 3RD AVE RM 500	NEW YORK	NY	10017	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	4/3/2025	NEW	$0
														Subtotal = $243,353

Issue Date FY: 2024 ( Subtotal = $243,421 )
2024	2024	PARTNERSHIP TO END ADDICTION	711 3RD AVE RM 500	NEW YORK	NY	10017	NEW YORK	USA	Drug Use and Addiction Research Programs	000	1	4/11/2024	NEW	$243,421
														Subtotal = $243,421

Grand Total All Awards = $730,171

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Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders among Adolescents with SUD

Award Number: R34DA056026

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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