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An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation

Award Number: R34CA286803
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation - ABSTRACT Cigarette smoking is the leading cause of preventable death and disability in the United States. Smoking cessation rates have stagnated in recent years, underscoring the need for innovative, accessible methods to support cessation. Emerging neurobiological and behavioral research indicate that the intentional sniffing of olfactory stimuli (OS) can fundamentally alter emotional states and reduce cigarette craving. Yet, no work has evaluated the potential for OS as an adjunctive intervention to facilitate successful smoking cessation. The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of OS to reduce cigarette craving with an established smartphone-based smoking cessation application. Our previously published work indicated that OS can relieve cigarette craving, and our recent pilot data showed that these effects may hold in the natural environment to help smokers resist smoking. This work provides the rationale for conducting the proposed clinical trial. Still, research is needed to determine the precise methodology for OS administration in the context of a smoking cessation attempt and to preliminarily evaluate the potential of OS when integrated with an established phone-based smoking cessation app before conducting a full-scale R01 smoking cessation trial. Building on our prior work, the current proposal aims to (1) refine the design and methodology for our novel, first-generation olfactory stimulation delivery system (OSDS; Phase I), and (2) determine the adjunctive benefit of the OSDS when integrated with a smartphone-based smoking cessation application (Smart-T; Phase II). This trial integrates theory-driven basic research derived from three disciplines independently related to smoking, but not jointly examined in the context of applied smoking research (olfaction, emotion, and cognition). Phase I will consist of a crossover, micro-randomized controlled trial in which treatment-seeking smokers (N=32) will receive the nicotine patch and engage in a self-guided quit attempt for 14 days. During the 14-day trial, participants will use our OSDS daily and complete daily ecological momentary assessments (EMAs). Phase I participants will complete a qualitative interview and quantitative survey at the end of the trial. Phase II will consist of a randomized controlled trial, in which participants (N = 100) will be randomized to our smartphone app for smoking cessation (Smart-T) with nicotine patch or the Smart-T app with nicotine patch and OSDS as an adjunctive feature (Smart-T+O). Participants will complete a baseline assessment, daily EMAs for 13 weeks (1-week pre-quit and 12-week post-quit), and a follow-up assessment at 12 weeks post-quit via the app. The proposed project will provide vital data to refine a protocol for assessing a phone-based cigarette smoking intervention that integrates an OS approach to craving relief. Accordingly, it will provide the data needed to successfully conduct a full-scale clinical trial evaluating this novel approach to smoking cessation. Irrespective of the outcome, the proposed research will advance knowledge regarding the integration of OS-based craving relief with a mobile health approach to smoking cessation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $281,325 )
2025	2025	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Cancer Cause and Prevention Research	000	2	9/1/2025	NON-COMPETING CONTINUATION	$281,325
														Subtotal = $281,325

Issue Date FY: 2024 ( Subtotal = $279,573 )
2024	2024	UNIVERSITY OF HOUSTON SYSTEM	4300 MARTIN LUTHER KING BLVD	HOUSTON	TX	77204	HARRIS	USA	Cancer Cause and Prevention Research	000	1	9/11/2024	NEW	$279,573
														Subtotal = $279,573

Grand Total All Awards = $560,898

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An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation

Award Number: R34CA286803

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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