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MIND Health: Mind-body Advances in Digestive Health

Award Number: R34AT013445
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/02/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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MIND Health: Mind-body Advances in Digestive Health - PROJECT ABSTRACT Abdominal pain disorders of gut-train interaction (AP-DGBIs), such as irritable bowel syndrome and functional dyspepsia, are highly prevalent in children and teenagers around the world and are associated with high financial cost to families of patients and the healthcare system broadly. Most patients with AP-DGBIs experience co- occurring physical conditions and symptoms, high degrees of emotional distress, impaired quality of life, and challenges with daily functioning, which are more pronounced among teenagers as compared to younger youth. Brain-gut behavior therapies that address the gastrointestinal-specific cognitions, affective responses, and behaviors that maintain or perpetuate symptoms in pediatric DGBIs, are the treatment modality with the strongest evidence for treating symptoms and improving quality of life in these teenagers. Mindfulness-based interventions (MBIs) are a class of brain-gut behavior therapies uniquely suited to address AP-DGBIs in teenagers; they have demonstrated promising evidence for alleviating GI symptoms in adults with AP-DGBIs and have shown efficacy for addressing physical and behavioral health symptoms, and improving daily functioning, among youth with other chronic conditions. Therefore, a strong rationale exists to adapt and implement MBIs for adolescents with AP-DGBIs. Digital MBIs are the logical choice for pediatric AP-DGBIs, as they address the known barriers to traditional, in-person MBIs, such as inaccessibility and cost. The purpose of this study is to adapt and evaluate a digital MBI for teenagers with AP-DGBIs. First, we will partner with teenagers with AP-DGBIs to co-design the digital MBI adaptations and test their usability. Next, we will conduct an initial evaluation of the digital MBI via a randomized controlled trial, with some participants using the digital MBI and other participants using a digitally- delivered control program with no mindfulness or psychological skills. Our ultimate goal is to apply digital technology solutions to enhance the reach and effectiveness of clinically and developmentally tailored interventions to improve the lives of so many teenagers affected by AP-DGBIs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $723,731 )
2026	2026	ANN & ROBERT H LURIE CHILDRENS HOSPITAL OF CHICAGO	225 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Research and Training in Complementary and Integrative Health	000	1	9/4/2026	NEW	$723,731
														Subtotal = $723,731

Grand Total All Awards = $723,731

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MIND Health: Mind-body Advances in Digestive Health

Award Number: R34AT013445

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/02/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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