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Development of a Mind Body Program to Reduce Knee Pain in Obese Osteoarthritis Patients with Comorbid Depression

Award Number: R34AT010370
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2023

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Development of a Mind Body Program to Reduce Knee Pain in Obese Osteoarthritis Patients with Comorbid Depression - PROJECT SUMMARY Development of a mind body program to reduce cartilage breakdown and knee pain in obese osteoarthritis patients with comorbid depression This is a R34 application that follows the recently released IMMPACT criteria, and the International Classification of Functioning, Disability and Health (ICF) framework to adapt a multimodal, theory grounded mind body program (The Relaxation Response Resilience Program; 3RP) with prior success in patients with medical illness in pilot and effectiveness studies for the needs of obese patients with knee osteoarthritis (OA) and depression and to specifically target increased physical activity (p3RP-OA). Depression, obesity and OA exacerbate one another and share a common pathophysiology involving systemic inflammation and pro- inflammatory cytokines, reflecting a complex mind-body interaction. Current treatments for knee OA offer little to no benefit over a placebo, and do not emphasize mind-body practices or physical activity to target the underlying pathophysiology. Physical activity alone has shown benefit in the treatment of depression, obesity and OA individually, but adequate implementation remains challenging. Our guiding hypothesis is that the synergistic interaction between mindfulness, adaptive thinking, positive psychology and healthy living skills of the 3RP adapted for the needs of OA patients and to target increased physical activity reduces pro- inflammatory cytokine expression while also promoting optimal mechanical loading of the cartilage will slow the progression of symptomatic knee OA. Toward this goal, this R34 proposal aims to 1) adapt the 3RP for the needs of knee OA patients with depression (PHQ-910) and obesity (BMI30 kg/m2) with a focus of increasing physical activity; and 2) establish the feasibility, credibility and acceptability of the programs and research procedures. Using the R34 NCCIH mechanism, we propose to use an iterative mixed methods strategy to adapt the 3RP for the specific needs of obese OA patients with depression including increased activity to maximize their feasibility, acceptability, and credibility. This R34 grant will set the stage for us to conduct a fully powered RCT through the R61/R33 mechanisms to assess the biopsychosocial mechanisms associated with OA progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5,560 )
2024	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	000	3	4/2/2024	NON-COMPETING CONTINUATION	-$5,560
														Subtotal = -$5,560

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	000	3	12/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $280,115 )
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	001	3	6/9/2022	NON-COMPETING CONTINUATION	$28,013
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	000	3	1/7/2022	NON-COMPETING CONTINUATION	$252,102
														Subtotal = $280,115

Issue Date FY: 2021 ( Subtotal = $242,800 )
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	001	2	2/10/2021	NON-COMPETING CONTINUATION	$24,281
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	000	2	1/8/2021	NON-COMPETING CONTINUATION	$218,519
														Subtotal = $242,800

Issue Date FY: 2020 ( Subtotal = $215,722 )
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Research and Training in Complementary and Integrative Health	000	1	12/23/2019	NEW	$215,722
														Subtotal = $215,722

Grand Total All Awards = $733,077

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Development of a Mind Body Program to Reduce Knee Pain in Obese Osteoarthritis Patients with Comorbid Depression

Award Number: R34AT010370

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2023

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