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Explant human skin perfusion model to study mechanisms of chemical injury and mitigation

Award Number: R34AR083572
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/08/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Explant human skin perfusion model to study mechanisms of chemical injury and mitigation - The changing geopolitical environment has increased the risk of mass population exposure to chemical vesicants-induced skin injuries from a large-scale incident improvised by a state or terrorist organization executed act but there are few countermeasures available having limited efficacy. The long-term goal is to develop a potent therapy for the treatment of chemical vesicant-induced injuries and its addition to the national stockpile. The overall objectives of this proposal are to (i) equip our laboratory with trained human resources and facilities that enable us to conduct research in the area of chemical vesicant-countermeasures development and (ii) understand the dynamics and mechanism(s) of vesicants-induced skin injuries. The central hypothesis is that understanding the dynamics of human skin response and the mechanism of the response to chemical vesicants is the key to designing efficient countermeasures. The rationale for this project is that our novel human skin perfusion model offers a unique opportunity to test the dynamics and mechanism(s) of human skin injury to vesicants in a controlled environment. The central hypothesis will be tested by pursuing three specific aims: 1); Equip our laboratory and acquire essential training to handle toxic vesicants and human skin perfusion system. 2); Implement a human skin bioreactor workflow for rigorous evaluation of the effects of NM and PAO vesicants 3) Investigate the mechanism(s) of vesicant-induced cell injury and death pathways in human skin. Under the first aim, we will procure additional safety equipment and get the training to handle toxic vesicants and operate the human skin perfusion system. The second aim will focus to study the dynamics of vesicants-induced injury in response to different doses and exposure times. While the third aim is focused to determine the mechanism(s) of the injury. The proposal is innovative, as it aims to perform pre-clinical mechanistic studies using a novel platform in human tissues. The proposed research is significant because the successful completion of this project will provide a strong scientific platform for investigating targeted countermeasures strategies against vesicant-induced skin injuries and due to the use of the human tissue as a model the approval pathway of countermeasures for inclusion into the national stockpile can be accelerated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $236,140 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	12/24/2025	NON-COMPETING CONTINUATION	$236,140
														Subtotal = $236,140

Issue Date FY: 2025 ( Subtotal = $236,140 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/12/2024	NON-COMPETING CONTINUATION	$236,140
														Subtotal = $236,140

Issue Date FY: 2024 ( Subtotal = $395,138 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	12/8/2023	NEW	$236,140
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	7/9/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	6/21/2024	SUPPLEMENT FOR EXPANSION	$158,998
														Subtotal = $395,138

Grand Total All Awards = $867,418

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Explant human skin perfusion model to study mechanisms of chemical injury and mitigation

Award Number: R34AR083572

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/08/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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