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Neurofeedback Processing Speed Training to Improve Social Functioning in Teenagers and Young Adults at Clinical High Risk for Psychosis

Award Number: R33MH111850
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Processing speed deficits are characteristic of schizophrenia and related to its functional impairment, including in its nascent stages, during a putatively prodromal or clinical high risk period. These cognitive deficits have proven relatively refractory to pharmacologic strategies, though the deficits can be improved with cognitive remediation programs in schizophrenia. The cognitive gains can then generalize to functional improvement, particularly early in the course of illness (i.e. first episode psychosis). Although processing speed deficits are also prevalent in young people identified as at clinical high risk (CHR) for psychosis (i.e. “psychosis risk syndrome”), and related to their concurrent impaired function and predictive of later psychosis (onset of which occurs in 20-25% of CHR cohorts), little research has focused on how to remediate these deficits in CHR patients. Remediating core cognitive deficits in CHR patients could plausibly address present functional impairment in these young people and moderate illness progression. We propose to conduct a double-blind randomized trial in 90 CHR patients to examine a focal processing speed training program versus an active control and a no treatment control in terms of improvement in processing speed and social function, and reduction in prodromal symptom severity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	3	11/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$30,091 )
2022	2020	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	3	5/20/2022	NON-COMPETING CONTINUATION	-$30,091
														Subtotal = -$30,091

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	3	12/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $321,053 )
2020	2020	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	3	12/10/2019	NON-COMPETING CONTINUATION	$288,947
2020	2020	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	001	3	2/17/2020	NON-COMPETING CONTINUATION	$32,106
														Subtotal = $321,053

Issue Date FY: 2019 ( Subtotal = $317,048 )
2019	2019	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	2	10/31/2018	NON-COMPETING CONTINUATION	$317,048
														Subtotal = $317,048

Issue Date FY: 2018 ( Subtotal = $320,068 )
2018	2018	HARTFORD HOSPITAL	80 SEYMOUR ST	HARTFORD	CT	06102	HARTFORD	USA	Mental Health Research Grants	000	1	12/27/2017	NEW	$320,068
														Subtotal = $320,068

Grand Total All Awards = $928,078

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Neurofeedback Processing Speed Training to Improve Social Functioning in Teenagers and Young Adults at Clinical High Risk for Psychosis

Award Number: R33MH111850

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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