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Leveraging behavioral economics to equitably implement cascade screening in individuals with familial hypercholesterolemia in partnership with the FH Foundation

Award Number: R33HL161752
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Leveraging behavioral economics to equitably implement cascade screening in individuals with familial hypercholesterolemia in partnership with the FH Foundation - Project Summary Familial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the United States. Eighty percent of people with FH have not yet been diagnosed, and this gap is even more robust for people from minoritized populations, including Black or African American people. Family cascade screening is an evidence- based practice that includes contacting and screening family members of people diagnosed with FH, but it is rarely implemented representing a care gap in all populations, and particularly in Black or African American people. The proposed work aims to use multi-methods to elucidate factors related to implementation of cascade screening in Black or African American people in pursuit of identifying targets for future strategies to mitigate this inequity. The parent grant supporting this Diversity Supplement is a hybrid effectiveness-implementation type III randomized controlled trial testing the comparative effectiveness of two strategies to implement family cascade screening with individuals with FH. Closing inequities in minoritized groups including African American or Black people, Asian or Asian American people, and women across racial groups is a focus of the parent grant, specifically by exploring equitable reach by sub-population, and in conducting interviews and centering diverse voices. Under the primary mentorship of Dr. Rinad Beidas, the candidate, Ms. Chynna Mills, will extend the aims of the parent grant using an established framework for health behavior to examine understudied multi-level factors using multi-methods that may be related to reach of family cascade screening for Black or African American people. In Aim 1, Ms. Mills will examine the relationship between a set of theoretically informed multi- level candidate variables and the primary outcome (reach) in 100 Black or African American probands. In Aim 2, Ms. Mills will explore mechanistic pathways of cascade screening reach via qualitative interviews. Ms. Mills has prior experience examining multi-level factors impacting Black or African American people’s participation in health interventions and is committed to a career as an independent investigator focused on improving implementation of and engagement with evidence-based practices for Black or African American populations. This Diversity Supplement will support the candidate’s development of an independent program of research through mentored training. Results will offer insights on how to close inequitable gaps in implementation of cascade screening with Black or African American populations and has the potential to lessen disparities in reach of family cascade screening for Black or African American people with FH and other heritable genetic disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	1/23/2025	NON-COMPETING CONTINUATION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	6/5/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $614,674 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	6/20/2024	NON-COMPETING CONTINUATION	$44,934
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	3	6/22/2024	SUPPLEMENT FOR EXPANSION	$64,217
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	3/2/2024	NON-COMPETING CONTINUATION	$505,523
														Subtotal = $614,674

Issue Date FY: 2023 ( Subtotal = $687,087 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	3/2/2023	EXTENSION WITH OR WITHOUT FUNDS	$593,202
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	2	8/22/2023	EXTENSION WITH OR WITHOUT FUNDS	$46,943
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	003	2	8/31/2023	EXTENSION WITH OR WITHOUT FUNDS	$46,942
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	2	3/24/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $687,087

Grand Total All Awards = $1,301,761

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Leveraging behavioral economics to equitably implement cascade screening in individuals with familial hypercholesterolemia in partnership with the FH Foundation

Award Number: R33HL161752

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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