Wednesday, March 12, 2025 3/12/2025

Enhancing cardiac and pulmonary rehabilitation adherence through home-based rehabilitation and behavioral nudges: ERA Nudge

Award Number: R33HL143324
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Our overarching goal is to increase enrollment, adherence and completion of cardiac and pulmonary rehabilitation (CR/PR) in a diverse population of low socioeconomic status; thus we will use a multi-pronged approach to increase referral, enrollment, adherence and completion. Our objectives are to 1) implement an EHR-based approach to increase referral to CR/PR, 2) evaluate the effect of choice of hospital or home-based rehabilitation on enrollment, adherence and completion and 3) evaluate the effect of nudge messaging on adherence and completion. This single site trial will be performed at Denver Health Medical Center, a large urban integrated safety net health system. We will provide all patients with the cellphone-based application, Movn, which will be used to deliver home-based rehabilitation and nudge messaging among patients randomized to those arms. In year 1 (R61 phase), we will 1) implement EHR-based interventions, 2) conduct a series of N of 1 trials to refine the nudge messages and tailor the interventions for diverse audiences, including Spanish-speaking patients, and 3) develop a one-page tool to present information, pros and cons of hospital and home-based rehabilitation for those randomized to choice. We will engage patients, providers, and health administrators to provide feedback on the messages and the information sheet, as well as engaging them in routine feedback during the study to help address potential barriers to implementation and help ensure sustainability. In the latter half of year 1, we will begin enrollment in the Phase II randomized trial. In years 2-5 (R33 phase), among patients eligible for CR or PR, we will conduct a patient level 2x2 randomized trial comparing: 1) hospital-based CR/PR and Movn alone; 2) hospital-based CR/PR and Movn with nudge messaging; 3) choice of hospital or home-based CR/PR and Movn alone; and 4) choice of hospital or home-based CR/PR and Movn with nudge messaging. The primary outcomes will be enrollment, adherence and completion of CR/PR. The study will also be evaluated using the RE-AIM framework.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	DENVER HEALTH AND HOSPITAL AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	1/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	DENVER HEALTH AND HOSPITAL AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	7/31/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	2/24/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $723,520 )
2022	2022	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	8/5/2022	NON-COMPETING CONTINUATION	$723,520
														Subtotal = $723,520

Issue Date FY: 2021 ( Subtotal = $721,223 )
2021	2021	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	4	7/19/2021	NON-COMPETING CONTINUATION	$721,223
2021	2020	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	3/4/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $721,223

Issue Date FY: 2020 ( Subtotal = $1,050,204 )
2020	2020	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	8/5/2020	NON-COMPETING CONTINUATION	$721,223
2020	2019	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	3/10/2020	EXTENSION WITH OR WITHOUT FUNDS	$328,981
														Subtotal = $1,050,204

Issue Date FY: 2019 ( Subtotal = $721,223 )
2019	2019	DENVER HEALTH AND HOSPITALS AUTHORITY	777 BANNOCK ST	DENVER	CO	80204	DENVER	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	9/12/2019	EXTENSION WITH OR WITHOUT FUNDS	$721,223
														Subtotal = $721,223

Grand Total All Awards = $3,216,170

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Enhancing cardiac and pulmonary rehabilitation adherence through home-based rehabilitation and behavioral nudges: ERA Nudge

Award Number: R33HL143324

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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