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Leveraging epidemiological data to inform the development of a just-in-time adaptive intervention for young adults co-using e-cigarettes and cannabis

Award Number: R33DA059831
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Leveraging epidemiological data to inform the development of a just-in-time adaptive intervention for young adults co-using e-cigarettes and cannabis - Emerging evidence indicates that co-use of cannabis and e-cigarettes may perpetuate dependence on both products and lead to adverse health outcomes in young people. Thus, there is an urgent need to examine the unique risk factors that drive higher substance use among young adults and rapidly translate findings into scalable interventions. Despite e-cigarette and cannabis co-use being common, it has not been studied in young adults representing unique geographical regions such as Hawaii. The current phased study will utilize epidemiological data from two sources (R61 phase) – the cross-sectional Behavioral Risk Factor Surveillance System (BRFSS) and the longitudinal Young Adult Health Behavior Survey (YAHB) – to guide the development of a Just-in-Time Adaptive Intervention (JITAI) for e-cigarette and cannabis co-use (R33) among young adults ages 18-30 from Hawaii. JITAIs allow for intervention components to be delivered in real-time through a smartphone application. In the R61 phase, we will identify the relative importance of various psychosocial determinants in predicting co-use among young adults. Across both surveys, we will examine associations between e-cigarette and/or cannabis use, rates (prevalence and proportion of use), patterns, and progression (initiation, escalation, and maintenance), with social (e.g., family/peer influence and substance use), community, and advertising/marketing influences. We hypothesize that low-income young adults will be identified as the most susceptible group for co-use and that social influences will be most highly associated with use, initiation, escalation, and maintenance. Findings will allow us to calibrate the proposed intervention and tailor the balance of JITAI components in the R33 phase. Following initial development of the new JITAI, we will conduct a pilot and qualitative interviews with 10 low-income young adults engaging in co-use to assess feasibility. After additional intervention refinements, we will conduct an RCT (2-group) of the JITAI with young adults recruited from community sources who co-use e-cigarettes and cannabis assigned to intervention (n=60) or ecological momentary assessment-only (n=60) to examine its impact on frequency and problem e-cigarette and/or cannabis use.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $681,667 )
2026	2026	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Drug Use and Addiction Research Programs	000	3	2/19/2026	EXTENSION WITH OR WITHOUT FUNDS	$681,667
														Subtotal = $681,667

Grand Total All Awards = $681,667

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Leveraging epidemiological data to inform the development of a just-in-time adaptive intervention for young adults co-using e-cigarettes and cannabis

Award Number: R33DA059831

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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