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Brain mechanisms of reducing polysubstance use following a novel body-mind intervention

Award Number: R33AT010138
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Brain mechanisms of reducing polysubstance use following a novel body-mind intervention - Tobacco use is the leading cause of cancer and the leading preventable cause of death. Alcohol use is responsible for ~88,000 deaths each year in the U.S. and is another primary preventable cause of cancer. The changing cannabis policies and the 8% increase in cannabis use in the last decade have brought new challenges for existing treatment efforts. Our recent studies among TTU college students indicate that over 50% of those who reported alcohol intoxication, tobacco use, or cannabis use in the past month were involved in two or more of these substances (alcohol, tobacco and cannabis - ATC). Growing evidence has shown that polysubstance use is associated with numerous and deleterious consequences for college-attending emerging adults, but they are often unmotivated to quit or reduce drug use. Therefore, there is an urgent need to address this critical public health issue of widespread polysubstance use in high risk college students. Despite multiple treatment efforts, outcomes are far from optimal since treatments often fail to capitalize on important target domains linked to addiction outcomes. Research shows that one target domain (mechanism) for ATC involves deficits in self-control networks including the prefrontal cortex (PFC), the anterior cingulate cortex (ACC), and the ACC-Striatum circuit. Based on previous research conducted by our team and others, self-control deficits have been linked to SUDs, and could be ameliorated through mindfulness meditation (MM) and/or EEG neurofeedback (NF), both of which target self-control networks and have the potential to minimize negative outcomes resulting from deficits in self-control. Although MM has shown promises in improving self- control and reducing ATC use, many struggle to engage in the mindfulness practice early in treatment. Promisingly, recent studies suggest that combining NF with MM may improve engagement with mindfulness practice and produce larger reductions in ATC use compared to MM alone. The goal of this project is to understand brain mechanisms of ATC reduction following brief IBMT, and optimize IBMT through EEG Neurofeedback (NF). We will assess self-control deficits and ATC use and examine the effects of IBMT and/or NF on improving self- control and reducing ATC use among TTU college students. Our study will be the first to reveal the brain mechanisms of combining mindfulness intervention and EEG neurofeedback for treating polysubstance use, and potentially provide preliminary evidence that the modulated self-control networks by IBMT+NF are associated with clinical benefits such as craving and ATC reduction in high risk college students.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Research and Training in Complementary and Integrative Health	000	5	8/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $830,815 )
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Research and Training in Complementary and Integrative Health	001	5	5/24/2024	NON-COMPETING CONTINUATION	$729,465
2024	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Research and Training in Complementary and Integrative Health	000	4	12/12/2023	EXTENSION WITH OR WITHOUT FUNDS	$101,350
														Subtotal = $830,815

Issue Date FY: 2023 ( Subtotal = $768,501 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Research and Training in Complementary and Integrative Health	000	4	8/30/2023	EXTENSION WITH OR WITHOUT FUNDS	$768,501
														Subtotal = $768,501

Grand Total All Awards = $1,599,316

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Brain mechanisms of reducing polysubstance use following a novel body-mind intervention

Award Number: R33AT010138

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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