Sunday, May 25, 2025 5/25/2025

MAPs for Peds: Development of a Microarray Patch for Delivery of Long-Acting Antiretrovirals for Treatment of Pediatric HIV Infection

Award Number: R33AI149642
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

MAPs for Peds: Development of a Microarray Patch for Delivery of Long-Acting Antiretrovirals for Treatment of Pediatric HIV Infection - PROJECT SUMMARY Microarray patches (MAPs), also known as microneedle patches, are a novel, needle-free delivery technology in development for drugs and vaccines. MAPs contain an array of dissolving micron-scale projections and are applied like a bandage, painlessly piercing the stratum corneum to facilitate intradermal delivery. Due to their ease of use and acceptability, MAPs can potentially improve adherence to treatment, particularly for children. We propose to develop a MAP containing long-acting antiretrovirals as an age-appropriate, long-acting drug delivery system to treat pediatric HIV infection, with a particular focus on suitability for use in young children. The MAP would be designed to require a short wear time (less than 1 hour) and deliver enough drug to provide a monthly (or less frequent) dosing regimen. In contrast to other long-acting dosage forms, such as injectables and implants, the MAP would be painless and could be administered at home by parents or caregivers. The first phase of the project will focus on defining pediatric MAP requirements and optimizing antiretroviral MAP formulations. In the first two years, the project team plans to: 1. Define target product profile targets and preferred user characteristics, identify stakeholder needs, and evaluate potential acceptability to inform product development. 2. Determine MAP parameters through physiologically-based pharmacokinetic modeling. 3. Design, manufacture, and characterize nanosuspension-loaded dissolving MAPs. Assuming promising results from the first phase, during the second phase of the project we will focus on verifying MAP performance in preclinical and end user studies. In the last three years, the project team plans to: 4. Assess in vivo drug delivery and pharmacokinetic extrapolation. 5. Assess pharmacokinetics and antiviral efficacy in non-human primates. 6. Conduct user-centered design development of MAP prototypes, conduct a risk analysis, and assess end user acceptability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $403,741 )
2025	2025	PATH	437 N 34TH ST	SEATTLE	WA	98103	KING	USA	Allergy and Infectious Diseases Research	000	6	4/24/2025	NON-COMPETING CONTINUATION	$403,741
														Subtotal = $403,741

Issue Date FY: 2024 ( Subtotal = $580,843 )
2024	2024	PATH	2201 WESTLAKE AVE STE 200	SEATTLE	WA	98121	KING	USA	Allergy and Infectious Diseases Research	000	5	5/16/2024	NON-COMPETING CONTINUATION	$580,843
														Subtotal = $580,843

Issue Date FY: 2023 ( Subtotal = $1,568,947 )
2023	2023	PATH	2201 WESTLAKE AVE SUITE 200	SEATTLE	WA	98121	KING	USA	Allergy and Infectious Diseases Research	000	4	3/16/2023	NON-COMPETING CONTINUATION	$981,583
2023	2022	PATH	2201 WESTLAKE AVE STE 200	SEATTLE	WA	98121	KING	USA	Allergy and Infectious Diseases Research	001	3	5/17/2023	EXTENSION WITH OR WITHOUT FUNDS	$587,364
														Subtotal = $1,568,947

Issue Date FY: 2022 ( Subtotal = $940,558 )
2022	2022	PATH	2201 WESTLAKE AVE SUITE 200	SEATTLE	WA	98121	KING	USA	Allergy and Infectious Diseases Research	001	3	6/23/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2022	PATH	2201 WESTLAKE AVE SUITE 200	SEATTLE	WA	98121	KING	USA	Allergy and Infectious Diseases Research	000	3	4/25/2022	EXTENSION WITH OR WITHOUT FUNDS	$940,558
														Subtotal = $940,558

Grand Total All Awards = $3,494,089

Top

All Categories

About

Search

Reports

Data Submission

Award Information

MAPs for Peds: Development of a Microarray Patch for Delivery of Long-Acting Antiretrovirals for Treatment of Pediatric HIV Infection

Award Number: R33AI149642

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer