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A facial expression-based personalization engine (FPE) for monitoring and modulating real-time effective engagement in cognitive training in older adults at risk for AD/ADRD

Award Number: R33AG084471
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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A facial expression-based personalization engine (FPE) for monitoring and modulating real-time effective engagement in cognitive training in older adults at risk for AD/ADRD - ABSTRACT How to ensure adherence to computerized cognitive training in unsupervised circumstances (e.g., at-home, self- administered) in older adults at risk for Alzheimer’s disease (AD) or AD related dementia (AD/ADRD) is understudied. The objective of the R61/R33 is to refine and test a novel facial expression-based personalization engine (FPE) for monitoring and modulating real-time effective engagement, with an ultimate goal of enhancing long-term adherence in unsupervised cognitive training in older adults at risk for AD/ADRD. Here, Effective engagement is defined as the extent to which someone is actively engaged and performing with significant attention and enjoyment while training, addressing a balance between adherence and cognitive gains/plasticity from the training. Based on previous work, including ours, we hypothesize that (1) mental fatigue revealed in facial expressions will reflect a trainee’s degree of effective engagement, which can be modified by modulating task novelty; (2) our proposed FPE will ensure the effective engagement in cognitive training by monitoring trainee facial expressions and modulating training in response, promoting the trainee’s long-term adherence to the training and cognitive plasticity. In R61 (Y1-Y2), we will generate the FPE for monitoring and modulating real- time engagement in cognitive trainings in older adults at risk for AD/ADRD by refining our established application programming interface using a Stage I design. In R33 (Y3-Y5), we will conduct a Stage II intervention efficacy study comparing effective engagement and adherence in unsupervised cognitive training between training programs with vs. without FPE in older adults at risk for AD/ADRD. We will address milestones proposed in both stages to (a) ensure the readiness of the proposed FPE for R33 (R61 milestone) and (b) evaluate and further revision of FPE for future implementation test (R33 milestone). Impact: the proposed FPE may assist in monitoring and improving effective engagement and adherence in older adults with unsupervised cognitive training. In the current application, we will test FPE in a cognitive training program called speed of processing training. However, such FPE may be embedded to any computerized cognitive training in future studies to help address adherence related issues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $524,107 )
2026	2026	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	001	4	8/19/2026	NON-COMPETING CONTINUATION	$524,107
2026	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	3	11/24/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $524,107

Issue Date FY: 2025 ( Subtotal = $536,061 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	3	9/11/2025	EXTENSION WITH OR WITHOUT FUNDS	$536,061
														Subtotal = $536,061

Grand Total All Awards = $1,060,168

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A facial expression-based personalization engine (FPE) for monitoring and modulating real-time effective engagement in cognitive training in older adults at risk for AD/ADRD

Award Number: R33AG084471

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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