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Advanced Development and Utilization of Assembled Aging Trajectory Files from Multiple Datasets

Award Number: R33AG068931
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Advanced Development and Utilization of Assembled Aging Trajectory Files from Multiple Datasets - PROJECT SUMMARY This goal of this project is to create a unique and comprehensive research repository of aging trajectory da- tasets, related resources, and analytic methods that can be used to answer new and important questions in aging and related sciences. Specifically, by harmonizing and merging multiple data sets this project will gener- ate the data infrastructure needed to understand change over time in care settings, geriatric syndromes, physi- cal functioning, and shared risk factors at multiple levels (patient, provider, community, healthcare system, and society) and across multiple domains (biological, behavioral, sociocultural, and physical/built environments) including chronic conditions and history of acute illness such as COVID-19, exposure to air pollution, neighbor- hood socioeconomic, and health care system factors (Aim 1). Analytic strategies will be developed for user- defined cohorts and their propensity score-matched controls, e.g., older adults who were living with chronic conditions including Alzheimer's disease and related dementias (ADRD), diabetes, heart failure, end-stage re- nal disease, metastatic cancer, and HIV. State-of-the-art analytic methods are used to identify patterns of ag- ing trajectories (care setting, geriatric syndromes, physical functioning) experienced by older adults during the final years of life and their association with shared risk factors and distal outcomes (Aim 2). From the assem- bled trajectory file in Aim 1, cohorts are derived by aligning an originating index time such as age cutoff point and time at diagnosis (e.g., ADRD, stroke, chronic kidney disease). Both a model-based approach and ma- chine learning algorithms are then used to discover multilevel and potentially interactive predictors of trajecto- ries (e.g., rapid functional decline in independent living beneficiaries) and specific outcomes (e.g., respiratory ventilator usage among Medicare beneficiaries diagnosed with COVID-19) (Aim 3). The unique resources are then shared to disseminate resources including datasets, documentation, source code, and methodology (Aim 4). At the end of this project, the research infrastructure to investigate the relationship between shared risk factors and aging trajectories will be ready to use and replicate, giving investigators unprecedented ability to solve new challenges in aging science. This will allow researchers to understand the underlying processes and systems associated with reversible periods of disability across care settings, and interventions that may be used to support recovery of function and reduction of geriatric syndromes including cognitive decline, for the purpose of reducing burdensome care transitions, and maintenance of functional independence. This project will also create the resources and methods needed to evaluate the impact of innovations and interventions im- plemented at the patient, provider, community, healthcare system, and society/policy levels to improve care quality and outcomes for older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	4	8/3/2026	NON-COMPETING CONTINUATION	$0
2026	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	002	4	8/18/2026	NON-COMPETING CONTINUATION	$0
2026	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	4	1/27/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $725,318 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	4	8/15/2025	NON-COMPETING CONTINUATION	$725,318
2025	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	2	3/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $725,318

Issue Date FY: 2024 ( Subtotal = $634,253 )
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	007	3	9/9/2024	EXTENSION WITH OR WITHOUT FUNDS	$751,218
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	003	2	3/26/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$133,441
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	001	1	3/26/2024	NEW	-$116,616
2024	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	2	10/31/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$116,965
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	005	2	6/19/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Trans-NIH Research Support	002	1	3/26/2024	SUPPLEMENT FOR EXPANSION	-$16,825
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	004	2	4/24/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	006	2	9/6/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $634,253

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	003	2	7/26/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$165,325
2023	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	1	7/13/2023	NEW	-$1,145,908
2023	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Aging Research	002	2	7/24/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,145,908
2023	2021	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Trans-NIH Research Support	001	1	7/13/2023	SUPPLEMENT FOR EXPANSION	-$165,325
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$143,503 )
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST STE 1	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	1	5/5/2022	NEW	-$143,503
														Subtotal = -$143,503

Issue Date FY: 2021 ( Subtotal = $2,633,910 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST STE 1	NEWARK	NJ	07107	ESSEX	USA	Trans-NIH Research Support	001	1	8/20/2021	SUPPLEMENT FOR EXPANSION	$314,000
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST STE 1	NEWARK	NJ	07107	ESSEX	USA	Aging Research	000	1	4/16/2021	NEW	$2,319,910
														Subtotal = $2,633,910

Grand Total All Awards = $3,849,978

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Advanced Development and Utilization of Assembled Aging Trajectory Files from Multiple Datasets

Award Number: R33AG068931

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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