Thursday, June 19, 2025 6/19/2025

Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant

Award Number: R25CA203650
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant - Abstract Given the rising prevalence of obesity, poor diet and physical inactivity, known in combination as “energy balance” or “energetics”, as well as their associations with cancer incidence and mortality, innovative research, clinical care and training of scientists are needed to lower the prevalence of these risk factors and in turn, lower cancer incidence and mortality rates. In September 2020, the NCI released its Fiscal Year 2022 Budget proposal, which includes obesity and cancer as a featured scientific topic and training the next generation of cancer researchers as a key investment. With NCI R25 support from 2016-2021, we developed and offered an annual one-week, in-residence Transdisciplinary Research in Energetics and Cancer (TREC) Training Course, followed by a yearlong mentoring program, that focused on energy balance and cancer research across the cancer control continuum. The overall goals of this Program were to educate, train and mentor 100 early career investigators, called TREC Fellows, from diverse academic backgrounds (i.e., basic, clinical and population sciences) in transdisciplinary research in energetics and cancer. For the first four years of TREC, we admitted and trained 97 Fellows from 57 different institutions. We are in our 5th year of our TREC Program and expect to recruit 20 more Fellows, for a total of 117 Fellows completing the TREC Training Program. TREC Fellows have published 270 manuscripts in peer-reviewed journals, with 62 published manuscripts including the TREC Fellow as first or senior author and including a TREC Faculty and/or Fellow as co-author. Since completing the Program, TREC Fellows have received 31 extramural grants, as principal investigator. Building upon the strengths of the previous five years but responsive to additional opportunities for training and further dissemination of the course, the goals of our competitive renewal are: 1) to offer a hybrid TREC Training Program with virtual TREC Faculty-led programs before the in-person workshop focused on increasing content knowledge; 2) followed by a 5-day in-person workshop focused on the Fellows’ research, networking and professional development; and 3) year-long mentorship between the Fellow and Faculty Mentor and Peer Mentor. Led by Dr. Melinda Irwin and drawing from the resources of the Yale School of Public Health, Yale Cancer Center, and ~20 expert TREC Faculty from across the country and 100+ TREC Fellow alumni from around the world, our TREC Program is innovative in that currently no training opportunity exists that focuses on energetics and cancer research. Our goal is to continue the TREC mission of training scientists to develop a cadre of well-trained, diverse researchers. The overall impact of this program will be defined by the degree to which TREC Fellows produce innovative research approaches and discoveries, thereby accelerating the dissemination and implementation of evidence-based approaches into everyday practice and patient care, in turn improving the health of the population at risk for cancer as well as cancer survivors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	9	4/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $309,107 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	9	8/23/2024	NON-COMPETING CONTINUATION	$309,107
														Subtotal = $309,107

Issue Date FY: 2023 ( Subtotal = $317,043 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	001	8	8/21/2023	NON-COMPETING CONTINUATION	$317,043
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	7	4/24/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $317,043

Issue Date FY: 2022 ( Subtotal = $337,221 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	003	7	8/19/2022	NON-COMPETING CONTINUATION	$221,370
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	001	6	11/12/2021	COMPETING CONTINUATION	$211,668
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	005	6	9/26/2022	COMPETING CONTINUATION	$45
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	002	6	1/27/2022	COMPETING CONTINUATION	$115,851
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	004	5	9/26/2022	NON-COMPETING CONTINUATION	-$45
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	5	11/12/2021	NON-COMPETING CONTINUATION	-$211,668
														Subtotal = $337,221

Issue Date FY: 2021 ( Subtotal = $201,335 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	6	9/15/2021	COMPETING CONTINUATION	$201,335
														Subtotal = $201,335

Issue Date FY: 2020 ( Subtotal = $268,927 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	5	6/26/2020	NON-COMPETING CONTINUATION	$268,927
														Subtotal = $268,927

Issue Date FY: 2019 ( Subtotal = $276,678 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	4	7/18/2019	NON-COMPETING CONTINUATION	$276,678
														Subtotal = $276,678

Issue Date FY: 2018 ( Subtotal = $252,567 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	3	6/14/2018	NON-COMPETING CONTINUATION	$252,567
														Subtotal = $252,567

Issue Date FY: 2017 ( Subtotal = $279,293 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	2	6/20/2017	NON-COMPETING CONTINUATION	$279,293
														Subtotal = $279,293

Issue Date FY: 2016 ( Subtotal = $318,119 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	1	6/6/2016	NEW	$318,119
														Subtotal = $318,119

Grand Total All Awards = $2,560,290

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Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant

Award Number: R25CA203650

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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