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WormAtlas and The Center for Nematode Anatomy

Award Number: R24OD042575
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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WormAtlas and The Center for Nematode Anatomy - Project Summary “WormAtlas and the Center for Nematode Anatomy” The nematode, Caenorhabditis elegans, is among the most widely utilized model organisms for biomedical research. Research with C. elegans has led to discoveries associated with cancer, aging, and neurodevelopment. Advantages of C. elegans include its highly invariant development, transparency allowing researchers to observe cellular processes in vivo, and its small size comprising only about 1,000 cells. In addition to C. elegans, several other nematode species have biomedical importance as human parasites or comparative models. Electron microscopy (EM) has been used extensively to characterize nematode anatomy. However, EM techniques and interpretation of EM micrographs are challenging and frequently rely on specialized expertise. Furthermore, only a small portion of EM micrographs are presented in any given publication, thereby hindering additional analyses. The long-term objective for the Center and this project is to be the preeminent source of anatomical knowledge and data on C. elegans and other nematodes for the research community and to help train graduate students and postdocs in the art of EM. We make anatomical data easily interpretable for novices, comprehensive for those seeking detailed information, and freely available through our online platforms, thereby contributing to overall rigor and reproducibility of researchers working on these nematodes. The Center does this by 1) publishing detailed information regarding the anatomy of the nematode in the form of annotated EM and light micrographs, graphical illustrations, and corresponding text as anatomical handbooks on our WormAtlas website. During the upcoming project, we will expand our offerings by developing handbooks on the human parasitic nematode Strongyloides stercoralis and the comparative model Pristionchus pacificus 2) We host and make available the largest collection of EM data for C. elegans and other nematodes through our online WormImage database. Most of these data were collected as photographic negatives and prints and subsequently digitized and annotated by the Center. During the upcoming period we will add new data sets of both C. elegans and other nematode species. Furthermore, we will collaborate with the NIH-funded BossDB repository to share fully aligned and segmented data sets. 3) The Center regularly provides practical training in modern EM methods for students and postdoctoral associates. The Center also tests and develops new EM methods for C. elegans. During the upcoming project period we will organize quarterly webinars on various aspects of nematode anatomy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $646,919 )
2026	2026	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST	URBANA	IL	61801	CHAMPAIGN	USA	Research Infrastructure Programs	000	1	7/16/2026	NEW	$646,919
														Subtotal = $646,919

Grand Total All Awards = $646,919

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WormAtlas and The Center for Nematode Anatomy

Award Number: R24OD042575

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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