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Use of DVC® systems to acquire and remotely view data for improved monitoring of animal models and their environment.

Award Number: R24OD037711
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2024
PERIOD OF PERFORMANCE END DATE: 09/14/2025

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Use of DVC® systems to acquire and remotely view data for improved monitoring of animal models and their environment. - ABSTRACT This application requests funds to acquire specialized laboratory mouse housing systems- Digital Ventilated Caging (DVC) designed to initiate a new generation of husbandry, breeding colony and animal welfare management, and research data acquisition. The requested equipment will improve NKI’s animal housing by establishing an ability for 24-hour remote monitoring of the cage microenvironment, promoting health, less disturbance of cage inhabitants, and normal baseline behavior and physiology, conditions necessary to produce more accurate animal models in brain-and-behavior studies. Such models, which, at NKI, aim at understanding the molecular basis of normal and diseased states, also have improved translational usefulness, including the development of early diagnostic and treatment abilities. Long-term monitoring of the behavior and activity of mice in their natural environment using non-intrusive methods in their home cages can better reveal their behavior and activity in their natural environment. Using home cage monitoring devices to track the activity levels of mice, researchers can evaluate phenotypic expression of inserted or deleted genes as well as the effectiveness of interventions, such as exercise and pharmaceutical treatments, on activity levels and all while improving overall general health and husbandry. The DVC systems, as a shared resource, will be used to provide GEM (genetically modified mice) models for multiple studies supported by funding from the NIH, Alzheimer’s Association, Jerome LeJeune Foundation, New Vision Research, the Dr. Ralph and Marian Falk Medical Research Trust, and the Templeton World Charity Foundation. Upgrading and modernizing animal caging systems along with continued Institutional funding for facility improvements further the NKI animal care and use program toward AAALAC accreditation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Infrastructure Programs	000	1	2/4/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $349,729 )
2024	2024	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Research Infrastructure Programs	000	1	9/3/2024	NEW	$349,729
														Subtotal = $349,729

Grand Total All Awards = $349,729

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Use of DVC® systems to acquire and remotely view data for improved monitoring of animal models and their environment.

Award Number: R24OD037711

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2024

PERIOD OF PERFORMANCE END DATE: 09/14/2025

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