Saturday, September 7, 2024
9/7/2024
Project Summary/Abstract The temperature of the ambient housing environment represents a major modifier of outcomes in many studies. Maintenance of precise temperature and humidity control minimizes contributions to variation in both behavioral and physiological outcome measures from differential recruitment of thermogenesis. Furthermore, the ability to house animals at precise temperatures outside of standard housing ranges (65-75°F) permits specific studies that rely on cold activation of adipose tissue, analyze metabolic demand without thermogenesis for body temperature maintenance, or create perturbations that may drive, protect, or modify pathology when modeling diseases such as Sudden Infant Death Syndrome, Malignant Hyperthermia or other disorders. Access to housing space that provides precise adjustable control of housing temperature is needed to facilitate these studies. The TSE-Systems Climatic Control Chambers would provide this missing component for extended duration animal housing at precise temperatures that is critical for the success of several metabolic, physiology, and neurologically focused research programs at Baylor College of Medicine.
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