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A National NHP Embryo Resource of Human Genetic Disease Models

Award Number: R24OD034055
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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A National NHP Embryo Resource of Human Genetic Disease Models - PROJECT SUMMARY The goal of this project is to develop (NHP) diseases NHP that diseases models uncurable of two female require in The in already staff discovered relevant cutting-edge aims: public, To training genetic research NHP disease a national resource for the preservation and use of non-human primate models of human genetic diseases. Numerous laboratories are developing novel therapies for genetic that require large animal models to assess safety and efficacy. Compared to rodents and other animals, models of human diseases have been far more valuable for developing new drugs and other approaches go on to be successfully used in humans. Recently, a variety of spontaneous NHP models of human genetic have been identified at the U.S. National Primate Research Centers (NPRCs). These NHP genetic present extraordinary opportunities to significantly advance the study and treatment of currently diseases, including the pre-clinical testing of state-of-the-art precision medicine approaches. constraints impact the efficient breeding and availability of these NHP models. First, since most the identified diseases display autosomal recessive i nheritance, on average only 1 in 4 offspring produced by allele carriers is homozygous and affected. There are often insufficient numbers of breeding age male and allele carriers to produce sufficient subjects in a timely way. Second, for ultra-rare alleles, breeding may the use of a l imited number of allele carriers located at multiple NPRC facilities. Third, r ecen increases demand for NHPs for vaccine research severely threatens the long-term availability of model allele carriers. overcome these challenges, we aim to generate a National NHP Model Embryo Resource (NNMER). Oregon NPRC (ONPRC) will optimize and implement state-of-the-art protocols for NHP gamete collection, vitro f ertilization, blastocyst genotyping and embryo cryopreservation of affected and carrier embryos of characterized disease models. Moreover, the ONPRC wil provide training and support for veterinary at five partnering NPRCs to ensure t he efficient collection of gametes from both current and newly disease model carriers located at each center. The long-term goal is to provide a biomedically- national resource, accessible to any investigator interested in NHP genetic models, that will enable preclinical research and therapeutic development. To achieve these oals, we propose the following (1) To establish a national NHP genetic disease model gamete, embryo and fibroblast resource and a searchable tool for the long-term preservation of and accessibility to valuable NHP disease models; support nationwide collection of NHP gametes and the generation of genotyped model embryos by providing in state-of-the-art assisted reproductive technologies; and (3) To promote widespread use of the NHP disease embryo resource through systematic outreach efforts aimed at reaching both clinicians and investigators nationwide. This proposed highly novel resource will provide powerful, genetically parallel, models to investigators and clinicians advancing studies to understand mechanisms of human genetic pathogenesis and to evaluate new therapeutic strategies. Several t To l g (2)


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $617,679 )
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	001	3	8/6/2025	NON-COMPETING CONTINUATION	$123,537
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	000	3	1/3/2025	NON-COMPETING CONTINUATION	$494,142
														Subtotal = $617,679

Issue Date FY: 2024 ( Subtotal = $672,595 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	000	2	12/21/2023	NON-COMPETING CONTINUATION	$538,076
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	001	2	5/21/2024	NON-COMPETING CONTINUATION	$134,519
														Subtotal = $672,595

Issue Date FY: 2023 ( Subtotal = $819,192 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	000	1	3/1/2023	NEW	$819,192
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Research Infrastructure Programs	001	1	7/19/2023	NEW	$0
														Subtotal = $819,192

Grand Total All Awards = $2,109,466

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A National NHP Embryo Resource of Human Genetic Disease Models

Award Number: R24OD034055

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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