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A genomic toolkit for functional interrogation of trait variation in an aquatic model

Award Number: R24OD030214
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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A genomic toolkit for functional interrogation of trait variation in an aquatic model - SUMMARY In the study of disease, the polygenic factors that lead to genetic adaptation in species, essentially who will be asymptomatic while under environmental stressors, mostly remain undiscovered. Without a comparative understanding of these unique features by cell type, that evolution has preserved, our efforts to more broadly implement precision medicine will be limited in multiple phenotypes. One of the most promising applications of evolutionary medicine has been the use of divergent animal models to deconstruct and uncover fundamental concepts of biological organization in great detail. The Mexican cavefish, Astyanax mexicanus provides a rapidly growing model system to apply principles of evolutionary medicine to study trait variation. We have implemented a toolbox of genetic tools that allow for functional interrogation of various traits in the Mexican cavefish, but key resources are missing. This model species consists of surface and cavefish populations that possess natural trait differentiation, often displaying genetic adaption associated with environmental change, without impacting health or longevity. The objectives of our studies are to generate three tiers of community requested resources: high-quality surface and cavefish genome assemblies, using powerful single-cell sequencing technology a cell atlas with differentiating gene expression data sets and targeted gene reporter constructs coupled with a spatial understanding of their gene regulatory effects. This compendium of resource data and methodology can serve a large community wishing to test various hypotheses of adaptation in this species and others. Our proposed research objectives are significant in that they will contribute comparative gene networks that reveal novel differences with a growing assemblage of gene candidates for human diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $665,336 )
2025	2025	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	000	4	4/17/2025	NON-COMPETING CONTINUATION	$665,336
														Subtotal = $665,336

Issue Date FY: 2024 ( Subtotal = $718,527 )
2024	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	001	3	5/17/2024	NON-COMPETING CONTINUATION	$143,706
2024	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	000	3	1/15/2024	NON-COMPETING CONTINUATION	$574,821
														Subtotal = $718,527

Issue Date FY: 2023 ( Subtotal = $724,263 )
2023	2023	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	000	2	3/7/2023	NON-COMPETING CONTINUATION	$724,263
														Subtotal = $724,263

Issue Date FY: 2022 ( Subtotal = $677,073 )
2022	2022	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	001	1	5/7/2022	NEW	$65,585
2022	2022	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Research Infrastructure Programs	000	1	3/15/2022	NEW	$611,488
														Subtotal = $677,073

Grand Total All Awards = $2,785,199

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A genomic toolkit for functional interrogation of trait variation in an aquatic model

Award Number: R24OD030214

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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