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Inducible Tissue-Specific Transgene Expression in Large Animal Biomedical Models

Award Number: R24OD011188
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2011
PERIOD OF PERFORMANCE END DATE: 07/31/2016

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Inducible Tissue-Specific Transgene Expression in Large Animal Biomedical Models - DESCRIPTION (provided by applicant): The overall goal of this research proposal is to develop inducible, tissue-specific expression of transgenes to produce large animal models of human disease. There is a critical need to expand functional genomics to non-rodent models and the limited application of technologies, which have been so successful in rodent models, in large animals requires an alternate approach. The specific objective of this proposal is to develop effective tissue-specific, inducible expression of transgenes in vitro, then utilize recombinant lentiviral vectors to deliver these transgenes into porcine zygotes and evaluate the expression platforms in resulting offspring. The target gene for these experiments will be Stearoyl-CoA desaturase (SCD-1) and will serve as an effective and efficient model for examining local control of gene expression in vivo. Although any number of genes could be utilized, SCD-1 has been documented to have an important role in lipid biosynthesis and its tissue specific expression is important in maintaining homeostasis. Therefore, the resulting animals will not only demonstrate the effectiveness of the technology platform, but also serve as a useful model of failed lipid metabolism in a tissue-specific manner. Development of this technology, and utilization of this gene target is central to investigation of diseases such as obesity, insulin resistance and associated metabolic disorders, as well as, muscle and hepatic steatosis. Most importantly, successful completion of this project will result in technological advancements useful to produce a wide variety of biomedical models in numerous large animal species, potentially targeting a huge range of genes, thus benefiting many of the NIH Institutes and Centers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$182 )
2017	2014	TEXAS A & M RESEARCH FOUNDATION	400 HARVEY MITCHELL PKWY STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Research Infrastructure Programs	000	4	1/12/2017	NON-COMPETING CONTINUATION	-$182
														Subtotal = -$182

Issue Date FY: 2014 ( Subtotal = $432,204 )
2014	2014	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Research Infrastructure Programs	000	4	6/19/2014	NON-COMPETING CONTINUATION	$432,204
														Subtotal = $432,204

Issue Date FY: 2013 ( Subtotal = $418,801 )
2013	2013	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Research Infrastructure Programs	000	3	7/3/2013	NON-COMPETING CONTINUATION	$418,801
														Subtotal = $418,801

Issue Date FY: 2012 ( Subtotal = $440,379 )
2012	2012	TEXAS A & M RESEARCH FOUNDATION	400 Harvey Mitchell Parkway S,	COLLEGE STATION	TX	77845	BRAZOS	USA	Research Infrastructure Programs	000	2	7/7/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$440,379
														Subtotal = $440,379

Grand Total All Awards = $1,291,202

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Inducible Tissue-Specific Transgene Expression in Large Animal Biomedical Models

Award Number: R24OD011188

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2011

PERIOD OF PERFORMANCE END DATE: 07/31/2016

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