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Enhanced Development of the Xiphophorus Model System

Award Number: R24OD011120
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2022

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Enhanced Development of the Xiphophorus Model System - Project Summary This R24 proposal outlines both resource (Aims 1 and 2) and research (Aim 3) components designed to enhance the Xiphophorus Genetic Stock Center (XGSC) that has operated within the United States since the 1930's; making it one of the oldest live animal resource centers worldwide and a national scientific treasure. The XGSC currently houses 58 pedigreed genetic lines representing 24 Xiphophorus species of live-bearing fishes in over 1,400 aquaria. The XGSC has provided pedigreed fish and materials to researchers in over 30 laboratories representing 11 countries. The traditional strength of the Xiphophorus experimental model involves the non-biased assessment of genetic inheritance patterns associated with complex phenotypes. The high genetic variability among Xiphophorus species and capability of producing fertile interspecies hybrids allows inheritance of any observable trait to be followed into individual backcross hybrid progeny. For example, genetic control of tumor susceptibility has been documented in both pure strains and in select Xiphophorus interspecies hybrids, for a variety of spontaneous and induced neoplasms, including several genetically distinct types of melanoma. Proposed improvements to Xiphophorus genomic capabilities promises to support new fundamental knowledge regarding; (a) shifts in the global transcriptional state of cells within the intact organism, (b) complex gene interactions brought about by interspecies hybridization, (c) the genetics underlying melanoma susceptibility, and (d) the initiation and progression of tumorigenesis. Given our preliminary data, we have high expectations for novel scientific findings in the next project period. Specifically, the XGSC will continuing to provide the research community with animals, enhanced resources, and user databases related to the genetically managed lines, and complete cryopreservation of germplasm from all XGSC lines. Enhancements to the genome assemblies will be made by application of new optical mapping (BioNano) and extra-long sequencing (PacBio) technologies. Finally, we will establish basal gene expression profiles for major organs and determine the rate of genetic transduction through the organism after external stimulus.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$230,717 )
2023	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	12	5/15/2023	NON-COMPETING CONTINUATION	-$21,473
2023	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	002	12	6/9/2023	NON-COMPETING CONTINUATION	-$19,444
2023	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	12	5/15/2023	NON-COMPETING CONTINUATION	-$189,799
														Subtotal = -$230,717

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	12	5/4/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = -$66,928 )
2020	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	12	5/13/2020	NON-COMPETING CONTINUATION	$0
2020	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	12	12/10/2019	NON-COMPETING CONTINUATION	-$66,928
														Subtotal = -$66,928

Issue Date FY: 2019 ( Subtotal = $771,327 )
2019	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	12	5/21/2019	NON-COMPETING CONTINUATION	$711,962
2019	2019	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	002	12	9/4/2019	SUPPLEMENT FOR EXPANSION	$59,365
2019	2018	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	NIH Office of Research on Women's Health	001	11	7/3/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $771,327

Issue Date FY: 2018 ( Subtotal = $809,470 )
2018	2018	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	11	5/27/2018	NON-COMPETING CONTINUATION	$579,475
2018	2018	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	NIH Office of Research on Women's Health	002	11	8/11/2018	SUPPLEMENT FOR EXPANSION	$97,175
2018	2018	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	11	6/18/2018	SUPPLEMENT FOR EXPANSION	$132,820
														Subtotal = $809,470

Issue Date FY: 2017 ( Subtotal = $550,500 )
2017	2017	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	003	10	8/3/2017	NON-COMPETING CONTINUATION	$28,973
2017	2017	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	002	10	6/3/2017	NON-COMPETING CONTINUATION	$521,527
2017	2016	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	9	5/26/2017	COMPETING CONTINUATION	$448,949
2017	2015	TEXAS STATE UNIVERSITY	601 UNIVERSITY DR	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	8	5/26/2017	NON-COMPETING CONTINUATION	-$448,949
														Subtotal = $550,500

Issue Date FY: 2016 ( Subtotal = $579,475 )
2016	2016	TEXAS STATE UNIVERSITY	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	002	9	8/19/2016	COMPETING CONTINUATION	$579,475
2016	2015	TEXAS STATE UNIVERSITY	601 UNIVERSITY DRIVE	SAN MARCOS	TX	786664684	HAYS	USA	Research Infrastructure Programs	000	8	5/13/2016	NON-COMPETING CONTINUATION	$0
2016	2015	TEXAS STATE UNIVERSITY	601 UNIVERSITY DRIVE	SAN MARCOS	TX	786664684	HAYS	USA	Research Infrastructure Programs	001	8	8/18/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $579,475

Issue Date FY: 2015 ( Subtotal = $568,113 )
2015	2015	TEXAS STATE UNIVERSITY	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	8	5/1/2015	NON-COMPETING CONTINUATION	$568,113
														Subtotal = $568,113

Issue Date FY: 2014 ( Subtotal = $620,365 )
2014	2014	TEXAS STATE UNIVERSITY	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	7	3/20/2014	NON-COMPETING CONTINUATION	$620,365
														Subtotal = $620,365

Issue Date FY: 2013 ( Subtotal = $817,297 )
2013	2013	TEXAS STATE UNIVERSITY-SAN MARCOS	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	6	8/16/2013	SUPPLEMENT FOR EXPANSION	$128,172
2013	2013	TEXAS STATE UNIVERSITY-SAN MARCOS	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	6	5/13/2013	NON-COMPETING CONTINUATION	$689,125
														Subtotal = $817,297

Issue Date FY: 2012 ( Subtotal = $677,710 )
2012	2012	TEXAS STATE UNIVERSITY-SAN MARCOS	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	000	5	5/7/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$599,508
2012	2012	TEXAS STATE UNIVERSITY-SAN MARCOS	601 UNIVERSITY DRIVE	SAN MARCOS	TX	78666	HAYS	USA	Research Infrastructure Programs	001	5	9/3/2012	SUPPLEMENT FOR EXPANSION	$78,202
														Subtotal = $677,710

Grand Total All Awards = $5,096,612

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Enhanced Development of the Xiphophorus Model System

Award Number: R24OD011120

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2022

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