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RECOMBINANT PROTEIN EXPRESSION FACILITY

Award Number: R24CA088336
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2001
PERIOD OF PERFORMANCE END DATE: 02/28/2006

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RECOMBINANT PROTEIN EXPRESSION FACILITY - A Comparative Cancer Center is being established at the College of Veterinary Medicine at Cornell with the aim of bridging basic research efforts in cell biology, signal transduction and virology with translational research and the clinical treatment of animal patients with cancer. The intention is for the Cancer Center to integrate the strengths of the Cornell community in structural biology, as well as new initiatives in Chemical Biology and Genomics, with basic and translational cancer research. Through the combined efforts of ten laboratories working in different areas of cell biology, signal transduction and virology, and five structural biology groups (three using X-ray crystallography and two using NMR), the three dimensional structures will be determined for a variety of proteins relevant to cell growth control and cancer. The ultimate goal is to use this structural information, together with small molecule chemistry to develop novel modulators/inhibitors of the protein activities, and examine the usefulness of these molecules as therapeutics in the veterinary clinic. An important step toward achieving this goal will be to establish a Recombinant Protein Expression Laboratory that will serve as a direct link between the cell/molecular biology groups affiliated with the Comparative Cancer Center and the structural laboratories. The facility will be managed by a Research Associate Professor and a full-time Research Support Specialist and will contain all of the necessary equipment and reagents for performing high level recombinant protein expression for structural determinations. The plan is to develop the Recombinant Protein Expression Laboratory in stages, with the ultimate goal being to establish a facility with full capability for the generation of recombinant proteins in E. coli, insect cells and mammalian cell systems for structural analyses. Each of the participating laboratories will have full access to the facility and its overall direction will be advised by an executive committee consisting of members from each of the major participating research areas and departments. The expectation is that the development of the Recombinant Protein Expression Laboratory will represent a key first step in coordinating campus wide efforts in basic research that will ultimately prove beneficial to animal cancers that are highly relevant and/or approximate the human disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $198,381 )
2005	2005	CORNELL UNIVERSITY, NEW YORK STATE VETERINARY COLLEGE	**	ITHACA	NY	14850	TOMPKINS	USA	Cancer Treatment Research	000	5	1/26/2005	NON-COMPETING CONTINUATION	$198,381
														Subtotal = $198,381

Issue Date FY: 2004 ( Subtotal = $192,603 )
2004	2004	CORNELL UNIVERSITY, NEW YORK STATE VETERINARY COLLEGE	**	ITHACA	NY	14850	TOMPKINS	USA	Cancer Treatment Research	000	4	2/10/2004	NON-COMPETING CONTINUATION	$192,603
														Subtotal = $192,603

Issue Date FY: 2003 ( Subtotal = $186,995 )
2003	2003	CORNELL UNIVERSITY, NEW YORK STATE VETERINARY COLLEGE	**	ITHACA	NY	14850	TOMPKINS	USA	Cancer Treatment Research	000	3		NON-COMPETING CONTINUATION	$186,995
														Subtotal = $186,995

Issue Date FY: 2002 ( Subtotal = $207,940 )
2002	2002	CORNELL UNIVERSITY, NEW YORK STATE VETERINARY COLLEGE	**	ITHACA	NY	14850	TOMPKINS	USA	Cancer Treatment Research	000	2	1/31/2002	NON-COMPETING CONTINUATION	$207,940
														Subtotal = $207,940

Issue Date FY: 2001 ( Subtotal = $200,370 )
2001	2001	CORNELL UNIVERSITY, NEW YORK STATE VETERINARY COLLEGE	**	ITHACA	NY	14850	TOMPKINS	USA	Cancer Treatment Research	000	1	2/13/2001	NEW	$200,370
														Subtotal = $200,370

Grand Total All Awards = $986,289

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RECOMBINANT PROTEIN EXPRESSION FACILITY

Award Number: R24CA088336

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2001

PERIOD OF PERFORMANCE END DATE: 02/28/2006

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