Wednesday, December 17, 2025 12/17/2025

Monkey Alcohol Tissue Research Resource (MATRR)

Award Number: R24AA019431
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2010
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Monkey Alcohol Tissue Research Resource (MATRR) - PROJECT SUMMARY The “Monkey Alcohol Tissue Research Resource” (MATRR) is a multiple PI research resource award from Oregon Health & Science University and Baylor University. The MATRR has been highly successful in providing the alcohol research community access to tissue and data generated from cohorts of monkeys that have completed a standard protocol to study voluntary alcohol self-administration. The procedure results in a wide distribution of average daily ethanol intakes (g/kg) and the MATRR bioinformatics has established reliable, robust categories of drinking that encompass low, binge, heavy and very heavy chronic intake patterns. The necropsy procedure is fully refined and allows for the highest quality harvesting of all organs and tissues in the body. Prior to necropsy, registered users and other interested parties are contacted for custom tissue preparations, otherwise frozen and fixed tissue remain in the MATRR until requests are made through a dedicated web resource. All tissues are accompanied by data on organismal and alcohol intake variables to aid in rapid publication of findings. Importantly, the MATRR provides an opportunity for laboratories with specific expertise in organ pathology, neuroscience and genomics the ability to extend their research to a primate model with similar genetics, developmental processes, endocrinology, immunology, physiology and neuroanatomy to humans. Thus, the MATRR is unique to the alcohol research field in promoting a translational resource for mechanistic studies of alcohol-induced pathologies. The MATRR resource has exceeded all expectations in terms of tissue generation, inventory control, tissue requests, tissue utilization, data analytics, novel data generated, publications, newly funded projects and new research directions. In this renewal, we propose to add 3 more cohorts, with an expected accumulation of tissues and data from 20 cohorts of monkeys (total n=240 (162 ethanol, 78 control)). This has positioned the MATRR to fill experimental designs requiring large number of individuals, for example genetic and in vivo imaging datasets. The inventory control is aided by a unique web-based interface that also serves to administratively evaluate and act upon tissue requests. In total, we have 226 registered users and have shipped over 3,813 tissue samples from 5,590 tissue and data requests. With each accepted request an MTA is filed and timely progress reports are automatically requested. In the past funding, the resource has been extremely successful in the number of publications (48 in 48 months) from 22 different laboratories at 13 unique universities or Institutes. There remain great opportunities in further building and refining this resource. Our goal is to have the MATRR bioinformatics integrate data across disciplines, organs and individuals to generate knew knowledge of chronic alcohol use disorders. Finally, we acknowledge that in addition to building critical numbers for large scale data analyses, the opportunity exists to study additional tissue (such as fetal), variations in the protocol (such as necropsy in abstinence) and additional datasets such as sonography for liver elasticity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	15	11/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $663,454 )
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	16	9/18/2025	COMPETING CONTINUATION	$663,454
														Subtotal = $663,454

Issue Date FY: 2024 ( Subtotal = $385,282 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	15	7/19/2024	NON-COMPETING CONTINUATION	$385,282
														Subtotal = $385,282

Issue Date FY: 2023 ( Subtotal = $444,125 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	14	7/31/2023	NON-COMPETING CONTINUATION	$444,125
2023	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	13	12/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $444,125

Issue Date FY: 2022 ( Subtotal = $515,290 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	13	7/26/2022	NON-COMPETING CONTINUATION	$515,290
														Subtotal = $515,290

Issue Date FY: 2021 ( Subtotal = $492,830 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	12	7/22/2021	NON-COMPETING CONTINUATION	$440,774
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	003	12	9/3/2021	SUPPLEMENT FOR EXPANSION	$52,056
2021	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	11	2/5/2021	COMPETING CONTINUATION	$21,907
2021	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	10	2/5/2021	NON-COMPETING CONTINUATION	-$21,907
														Subtotal = $492,830

Issue Date FY: 2020 ( Subtotal = $588,310 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	11	9/8/2020	SUPPLEMENT FOR EXPANSION	$58,916
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	11	8/4/2020	COMPETING CONTINUATION	$529,394
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	002	11	9/11/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $588,310

Issue Date FY: 2019 ( Subtotal = $513,307 )
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	10	7/30/2019	NON-COMPETING CONTINUATION	$513,307
														Subtotal = $513,307

Issue Date FY: 2018 ( Subtotal = $522,037 )
2018	2018	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	9	7/30/2018	NON-COMPETING CONTINUATION	$522,037
														Subtotal = $522,037

Issue Date FY: 2017 ( Subtotal = $531,588 )
2017	2017	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	8	7/19/2017	NON-COMPETING CONTINUATION	$531,588
														Subtotal = $531,588

Issue Date FY: 2016 ( Subtotal = $632,234 )
2016	2016	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	001	7	9/19/2016	SUPPLEMENT FOR EXPANSION	$92,030
2016	2016	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	7	7/18/2016	NON-COMPETING CONTINUATION	$540,204
														Subtotal = $632,234

Issue Date FY: 2015 ( Subtotal = $549,049 )
2015	2015	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	6	8/25/2015	COMPETING CONTINUATION	$549,049
2015	2014	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97201	MULTNOMAH	USA	Alcohol Research Programs	001	5	8/25/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $549,049

Issue Date FY: 2014 ( Subtotal = $723,781 )
2014	2014	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	5	7/14/2014	NON-COMPETING CONTINUATION	$723,781
														Subtotal = $723,781

Issue Date FY: 2013 ( Subtotal = $709,165 )
2013	2013	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	4	7/16/2013	NON-COMPETING CONTINUATION	$709,165
														Subtotal = $709,165

Issue Date FY: 2012 ( Subtotal = $780,903 )
2012	2012	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	3	7/11/2012	NON-COMPETING CONTINUATION	$780,903
														Subtotal = $780,903

Issue Date FY: 2011 ( Subtotal = $797,394 )
2011	2011	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	2	7/28/2011	NON-COMPETING CONTINUATION	$797,394
														Subtotal = $797,394

Issue Date FY: 2010 ( Subtotal = $853,145 )
2010	2010	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK ROAD	PORTLAND	OR	97239	MULTNOMAH	USA	Alcohol Research Programs	000	1	9/17/2010	NEW	$853,145
														Subtotal = $853,145

Grand Total All Awards = $9,701,894

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Monkey Alcohol Tissue Research Resource (MATRR)

Award Number: R24AA019431

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2010

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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