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Optimization of delivery of HEX for treatment of primary amebic encephalitis

Award Number: R21TR005502
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Optimization of delivery of HEX for treatment of primary amebic encephalitis - Project Summary Brain infections by the pathogenic free-living amoeba Naegleria fowleri are life-threatening and typically (>95% of the time) result in patient fatality. We have identified a potent inhibitor, HEX, of the amoeba enzyme enolase (NfENO), that is well-tolerated in mammals and can extend life of infected rodents. The goal of this proposal is to optimize delivery of HEX to achieve curative concentrations in the brain. To date, resolution of brain distribution has been challenging due to the small size and charged nature of HEX. Here, we will develop mass spectrometry methods required to assess brain distribution of the inhibitor which will enable optimization of delivery approaches and schedules. Additionally, we will score the value of partner drugs in the treatment of disease in a rodent model. Together, these experiments will serve as a key step in progressing HEX toward investigational new drug status for N. fowleri infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $419,375 )
2025	2025	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	National Center for Advancing Translational Sciences	000	1	5/29/2025	NEW	$419,375
														Subtotal = $419,375

Grand Total All Awards = $419,375

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Optimization of delivery of HEX for treatment of primary amebic encephalitis

Award Number: R21TR005502

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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